Prognostic significance of non-HPV16 genotypes in oropharyngeal squamous cell carcinoma

Highlights • First to study the prognostic significance of non-HPV16 genotypes with p16 status. • HPV16-positve oropharynx tumors have better survival than non-HPV16-positive genotypes. • The survival benefit for HPV16-positve genotypes holds for tumors positive for p16, but not for p16-negative tum...

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Published inOral oncology Vol. 61; pp. 98 - 103
Main Authors Mazul, Angela L., PhD, MPH, Rodriguez-Ormaza, Nidia, MD, MPH, Taylor, James M., MPH, Desai, Dipan D, Brennan, Paul, PhD, MS, Anantharaman, Devasena, PhD, MSc, Gheit, Tarik, PhD, Tommasino, Massimo, PhD, Abedi-Ardekani, Behnoush, MD, Olshan, Andrew F., PhD, MS, Zevallos, Jose P., MD, MPH
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2016
Subjects
Aged
Alphapapillomavirus - genetics
Carcinoma, Squamous Cell - virology
Female
Head and neck cancer
Hematology, Oncology and Palliative Medicine
HPV
HPV16
Humans
Male
Middle Aged
Oropharyngeal cancer
Oropharyngeal Neoplasms - virology
Otolaryngology
p16
Papillomavirus Infections - virology
Proportional Hazards Models
Survival Analysis
Head and neck cancer
p16
Oropharyngeal cancer
HPV
HPV16
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Summary:Highlights • First to study the prognostic significance of non-HPV16 genotypes with p16 status. • HPV16-positve oropharynx tumors have better survival than non-HPV16-positive genotypes. • The survival benefit for HPV16-positve genotypes holds for tumors positive for p16, but not for p16-negative tumors.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2016.08.019