A Novel Hydrophilic, Antibacterial Chitosan-Based Coating Prepared by Ultrasonic Atomization Assisted LbL Assembly Technique

• Published in: Journal of functional biomaterials Vol. 14; no. 1; p. 43
• Main Authors: Wang, Xiaoyu, Zhou, Yuyang, Johnson, Melissa, Milne, Cameron, A, Sigen, Li, Yening, Wang, Wenxin, Zhang, Nan, Xu, Qian
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2023; MDPI
• Subjects: Acids; Aldehydes; Amino groups; antibacterial; Antibacterial activity; Antibacterial agents; Antibacterial materials; Antimicrobial agents; Assembly; Atomizing; Biocompatibility; Biological products; Biomaterials; Biomedical materials; Cell viability; Chitosan; Coating; Coatings; Contact angle; Digital cameras; E coli; Fourier transforms; Functional groups; hydrophilic; Hydrophilicity; Industrial production; Infrared analysis; Infrared spectroscopy; Medical equipment; Methods; Molecular weight; Oxidation; Particle size; PLA; Plasma; Polylactic acid; Polymers; Viscosity; Ireland; United Kingdom > UK; China; hydrophilic; chitosan; antibacterial; coating; PLA
• ISSN: 2079-4983; 2079-4983
• DOI: 10.3390/jfb14010043

To explore the potential applicability of chitosan (CTS), we prepared aldehyde chitosan (CTS-CHO) with chitosan and sodium periodate via oxidation reaction and then a chitosan-based hydrophilic and antibacterial coating on the surface of poly (lactic acid) (PLA) film was developed and characterized. The oxidation degree was determined by Elemental analyser to be 12.53%, and a Fourier transform infrared spectroscopy was used to characterize the structure of CTS-CHO. It was evident that CTS-CHO is a biocompatible coating biomaterial with more than 80% cell viability obtained through the Live/Dead staining assay and the alamarBlue assay. The hydrophilic and antibacterial CTS-CHO coating on the PLA surface was prepared by ultrasonic atomization assisted LbL assembly technique due to Schiff's base reaction within and between layers. The CTS-CHO coating had better hydrophilicity and transparency, a more definite industrialization potential, and higher antibacterial activity at experimental concentrations than the CTS coating. All of the results demonstrated that the ultrasonic atomization-assisted LbL assembly CTS-CHO coating is a promising alternative for improving hydrophilicity and antibacterial activity on the PLA surface. The functional groups of CTS-CHO could react with active components with amino groups via dynamic Schiff's base reaction and provide the opportunity to create a drug releasing surface for biomedical applications.