Inflammatory Response and Immune Regulation in Brain-Heart Interaction after Stroke

Cerebrocardiac syndrome (CCS) is one of the secondary myocardial injuries after stroke. Cerebrocardiac syndrome may result in a poor prognosis with high mortality. Understanding the mechanism of the brain-heart interaction may be crucial for clinical treatment of pathological changes in CCS. Accumul...

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Published inCardiovascular therapeutics Vol. 2022; pp. 2406122 - 7
Main Authors Zou, Lihua, Han, Ruquan
Format Journal Article
LanguageEnglish
Published England Hindawi 16.11.2022
John Wiley & Sons, Inc
Hindawi Limited
Hindawi-Wiley
Subjects
Antigens
Atrophy
Blood platelets
Blood-brain barrier
Cardiac arrhythmia
Catecholamines
Cytokines
Heart
Hematoma
Hemorrhage
Immune system
Inflammation
MicroRNAs
Nervous system
Neutrophils
Permeability
Proteins
Review
Signal transduction
Spleen
Stroke
Traumatic brain injury
Tumor necrosis factor-TNF
Veins & arteries
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Summary:Cerebrocardiac syndrome (CCS) is one of the secondary myocardial injuries after stroke. Cerebrocardiac syndrome may result in a poor prognosis with high mortality. Understanding the mechanism of the brain-heart interaction may be crucial for clinical treatment of pathological changes in CCS. Accumulating evidence suggests that the inflammatory response is involved in the brain-heart interaction after stroke. Systemic inflammatory response syndrome (SIRS) evoked by stroke may injure myocardial cells directly, in which the interplay between inflammatory response, oxidative stress, cardiac sympathetic/parasympathetic dysfunction, and splenic immunoregulation may be also the key pathophysiology factor. This review article summarizes the current understanding of inflammatory response and immune regulation in brain-heart interaction after stroke.
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Academic Editor: Jiacheng Sun
ISSN:1755-5914
1755-5922
DOI:10.1155/2022/2406122