Hypoxia-regulated microRNAs in human cancer

• Published in: Acta pharmacologica Sinica Vol. 34; no. 3; pp. 336 - 341
• Main Authors: Shen, Guomin, Li, Xiaobo, Jia, Yong-feng, Piazza, Gary A, Xi, Yaguang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2013; Nature Publishing Group
• Subjects: Biomedical and Life Sciences; Biomedicine; Cell Hypoxia - genetics; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Immunology; Internal Medicine; Medical Microbiology; microRNA; MicroRNAs - genetics; Neoplasms - blood supply; Neoplasms - genetics; Neoplasms - metabolism; Neovascularization, Pathologic - genetics; Pharmacology/Toxicology; Review; Up-Regulation; Vaccine; 人类; 小分子RNA; 癌症; 细胞周期调控; 缺氧条件; 缺氧诱导因子1; 肿瘤细胞; hypoxia; chemoresistance; human cancer; cell cycle; angiogenesis; microRNA; apoptosis; HIF1; radioresistance; cancer metastasis
• ISSN: 1671-4083; 1745-7254; 1745-7254
• DOI: 10.1038/aps.2012.195

Hypoxia plays an important role in the tumor microenvironment by allowingthe development and maintenance of cancer cells, but the regulatory mechanisms by which tumor cells adapt to hypoxic conditions are not yet well understood. MicroRNAs are recognized as a new class of master regulators that control gene expression and are responsible for many normal and pathological cellular processes. Studies have shown that hypoxia inducible factor 1 （HIF1） regulates a panel of microRNAs, whereas some of microRNAs target HIFI. The interaction between microRNAs and HIF1 can account for many vital events relevant to tumorigenesis, such as angiogenesis, metabolism, apoptosis, cell cycle regulation, proliferation, metastasis, and resistance to anticancer therapy. This review will summarize recent findings on the roles of hypoxia and microRNAs in human cancer and illustrate the machinery by which microRNAs interact with hypoxia in tumor cells. It is expected to update our knowledge about the regulatory roles of microRNAs in regulating tumor microenvi- ronments and thus benefit the development of new anticancer drugs.