Hypoxia-regulated microRNAs in human cancer

Hypoxia plays an important role in the tumor microenvironment by allowingthe development and maintenance of cancer cells, but the regulatory mechanisms by which tumor cells adapt to hypoxic conditions are not yet well understood. MicroRNAs are recognized as a new class of master regulators that cont...

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Bibliographic Details
Published inActa pharmacologica Sinica Vol. 34; no. 3; pp. 336 - 341
Main Authors Shen, Guomin, Li, Xiaobo, Jia, Yong-feng, Piazza, Gary A, Xi, Yaguang
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.03.2013
Nature Publishing Group
Subjects
Biomedical and Life Sciences
Biomedicine
Cell Hypoxia - genetics
Gene Expression Regulation
Humans
Hypoxia-Inducible Factor 1, alpha Subunit - genetics
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Immunology
Internal Medicine
Medical Microbiology
microRNA
MicroRNAs - genetics
Neoplasms - blood supply
Neoplasms - genetics
Neoplasms - metabolism
Neovascularization, Pathologic - genetics
Pharmacology/Toxicology
Review
Up-Regulation
Vaccine
人类
小分子RNA
癌症
细胞周期调控
缺氧条件
缺氧诱导因子1
肿瘤细胞
hypoxia
chemoresistance
human cancer
cell cycle
angiogenesis
microRNA
apoptosis
HIF1
radioresistance
cancer metastasis
Online AccessGet full text
ISSN1671-4083
1745-7254
1745-7254
DOI10.1038/aps.2012.195

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Summary:Hypoxia plays an important role in the tumor microenvironment by allowingthe development and maintenance of cancer cells, but the regulatory mechanisms by which tumor cells adapt to hypoxic conditions are not yet well understood. MicroRNAs are recognized as a new class of master regulators that control gene expression and are responsible for many normal and pathological cellular processes. Studies have shown that hypoxia inducible factor 1 （HIF1） regulates a panel of microRNAs, whereas some of microRNAs target HIFI. The interaction between microRNAs and HIF1 can account for many vital events relevant to tumorigenesis, such as angiogenesis, metabolism, apoptosis, cell cycle regulation, proliferation, metastasis, and resistance to anticancer therapy. This review will summarize recent findings on the roles of hypoxia and microRNAs in human cancer and illustrate the machinery by which microRNAs interact with hypoxia in tumor cells. It is expected to update our knowledge about the regulatory roles of microRNAs in regulating tumor microenvi- ronments and thus benefit the development of new anticancer drugs.
Bibliography:microRNA; hypoxia; HIF1; human cancer; angiogenesis; apoptosis; cell cycle; cancer metastasis; chemoresistance; radiore-sistance
Hypoxia plays an important role in the tumor microenvironment by allowingthe development and maintenance of cancer cells, but the regulatory mechanisms by which tumor cells adapt to hypoxic conditions are not yet well understood. MicroRNAs are recognized as a new class of master regulators that control gene expression and are responsible for many normal and pathological cellular processes. Studies have shown that hypoxia inducible factor 1 （HIF1） regulates a panel of microRNAs, whereas some of microRNAs target HIFI. The interaction between microRNAs and HIF1 can account for many vital events relevant to tumorigenesis, such as angiogenesis, metabolism, apoptosis, cell cycle regulation, proliferation, metastasis, and resistance to anticancer therapy. This review will summarize recent findings on the roles of hypoxia and microRNAs in human cancer and illustrate the machinery by which microRNAs interact with hypoxia in tumor cells. It is expected to update our knowledge about the regulatory roles of microRNAs in regulating tumor microenvi- ronments and thus benefit the development of new anticancer drugs.
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ISSN:1671-4083
1745-7254
1745-7254
DOI:10.1038/aps.2012.195