Adaptive Radiotherapy for Anatomical Changes

The anatomy of cancer patients changes between radiation treatment planning and delivery as well as over the course of radiotherapy. Adaptive radiotherapy (ART) aims to deliver radiation accurately and precisely in the presence of such changes. To that end, ART uses an imaging feedback loop to quant...

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Bibliographic Details
Published inSeminars in radiation oncology Vol. 29; no. 3; pp. 245 - 257
Main Authors Sonke, Jan-Jakob, Aznar, Marianne, Rasch, Coen
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2019
Subjects
Anatomic Variation
Feedback
Humans
Neoplasms - diagnostic imaging
Neoplasms - radiotherapy
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Image-Guided - methods
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Summary:The anatomy of cancer patients changes between radiation treatment planning and delivery as well as over the course of radiotherapy. Adaptive radiotherapy (ART) aims to deliver radiation accurately and precisely in the presence of such changes. To that end, ART uses an imaging feedback loop to quantify these changes and modify the treatment plan accordingly. This paper provides an overview of anatomical changes occurring over the course of therapy and various adaptive strategies developed to account for those. Moreover, residual uncertainties present in adaptive radiotherapy are discussed as well as required tools, potential pitfalls and remaining challenges.
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ISSN:1053-4296
1532-9461
1532-9461
DOI:10.1016/j.semradonc.2019.02.007