CENTRAL ADRENOCEPTORS AND CHOLINOCEPTORS IN CARDIOVASCULAR CONTROL

• Published in: British journal of pharmacology Vol. 63; no. 1; pp. 7 - 15
• Main Authors: BHARGAVA, K.P., JAIN, L.P., SAXENA, A.K., SINHA, J.N., TANGRI, K.K.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.1978
• Subjects: Animals; Cardiovascular Physiological Phenomena; Cardiovascular System - drug effects; Cats; Central Nervous System - physiology; Female; Hypothalamus, Posterior - drug effects; Male; Medulla Oblongata - drug effects; Parasympathomimetics - pharmacology; Receptors, Adrenergic - physiology; Receptors, Cholinergic - physiology; Spinal Cord - drug effects; Sympathomimetics - pharmacology
• ISSN: 0007-1188; 1476-5381
• DOI: 10.1111/j.1476-5381.1978.tb07768.x

1 In cats anaesthetized with chloralose, adrenoceptor and cholinoceptor agonists and antagonists were localized to the posterior hypothalamus (PH), lateral medullary pressor area (LMPA) and spinal autonomic loci to delineate the role of central cholinoceptors and adrenoceptors in cardiovascular control. 2 All along the neuroaxis, the α‐adrenoceptors seem to subserve an inhibitory and the β‐adrenoceptors a facilitatory role in cardiovascular control. There appears to be a predominance of α‐adrenoceptors at the medullary level and β‐adrenoceptors at the hypothalamic level. 3 The nicotinic cholinoceptors at the hypothalamic, medullary and spinal levels were facilitatory, whereas muscarinic cholinoceptors were inhibitory for cardiovascular control. However, muscarinic receptors were undetectable at the posterior hypothalamus. 4 The central cardiovascular effects of nicotine are attributed to nicotinic receptor activation and release of central catecholamines. 5 There appears to be a relationship between central cholinergic and adrenergic mechanisms in cardiovascular control.