Catalytic Fehling's Reaction: An Efficient Aerobic Oxidation of Aldehyde Catalyzed by Copper in Water

• Published in: Angewandte Chemie International Edition Vol. 55; no. 36; pp. 10806 - 10810
• Main Authors: Liu, Mingxin, Li, Chao-Jun
• Format: Journal Article
• Language: English
• Published: WEINHEIM Blackwell Publishing Ltd 26.08.2016; Wiley; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Aldehydes; Catalysis; Chemistry; Chemistry, Multidisciplinary; Chromatography; Copper; homogeneous catalysis; Oxidation; Oxidizing agents; Oxygen; Physical Sciences; Purification; reaction mechanisms; Science & Technology; ALCOHOLS; ACETYLACETONATE COMPLEXES; homogeneous catalysis; oxidation; reaction mechanisms; NHC; copper; MOLECULAR-OXYGEN; CARBOXYLIC-ACIDS
• ISSN: 1433-7851; 1521-3773; 1521-3773
• DOI: 10.1002/anie.201604847

The first example of homogeneous copper‐catalyzed aerobic oxidation of aldehydes is reported. This method utilizes atmospheric oxygen as the sole oxidant, proceeds under extremely mild aqueous conditions, and covers a wide range of various functionalized aldehydes. Chromatography is generally not necessary for product purification. Without ‘Fehl ’: The first example of homogeneous copper‐catalyzed aerobic oxidation of aldehydes is reported. This method utilizes atmospheric oxygen as the sole oxidant, proceeds under extremely mild aqueous conditions, and covers a wide range of various functionalized aldehydes. Chromatography is generally not necessary for product purification.