Intranasal cooling with or without intravenous cold fluids during and after cardiac arrest in pigs

• Published in: Acta anaesthesiologica Scandinavica Vol. 54; no. 4; pp. 494 - 501
• Main Authors: COVACIU, L., ALLERS, M., LUNDERQUIST, A., RUBERTSSON, S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2010; Blackwell
• Subjects: Anestesi och intensivvård; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthesiology and Intensive Care; Animals; Biological and medical sciences; Body Temperature - physiology; Brain - physiology; Cardiopulmonary Resuscitation - methods; Catheterization; Catheterization, Swan-Ganz; Clinical Medicine; Electrocardiography; Heart Arrest - metabolism; Heart Arrest - therapy; Hemodynamics - physiology; Hypothermia, Induced - methods; Infusions, Intravenous; Intracranial Pressure - physiology; Klinisk medicin; Medical and Health Sciences; Medical sciences; MEDICIN; Medicin och hälsovetenskap; MEDICINE; Nasal Cavity; Oxygen - blood; Rewarming; Swine; Ventricular Fibrillation - physiopathology; Ventricular Fibrillation - therapy; Vertebrata; Cardiocirculatory arrest; Mammalia; Cooling; Intravenous administration; Cardiovascular disease; Anesthesia; Artiodactyla; Ungulata; Pig
• ISSN: 0001-5172; 1399-6576; 1399-6576
• DOI: 10.1111/j.1399-6576.2009.02157.x

Background: Intranasal balloon catheters circulated with cold saline have previously been used for the induction and maintenance of selective brain cooling in pigs with normal circulation. In the present study, we investigated the feasibility of therapeutic hypothermia initiation, maintenance and rewarming using such intranasal balloon catheters with or without addition of intravenous ice‐cold fluids during and after cardiac arrest treatment in pigs. Material and methods: Cardiac arrest was induced in 20 anaesthetised pigs. Following 8 min of cardiac arrest and 1 min of cardiopulmonary resuscitation (CPR), cooling was initiated after randomisation with either intranasal cooling (N) or combined with intravenous ice‐cold fluids (N+S). Hypothermia was maintained for 180 min, followed by 180 min of rewarming. Brain and oesophageal temperatures, haemodynamic variables and intracranial pressure (ICP) were recorded. Results: Brain temperatures reductions after cooling did not differ (3.8 ± 0.7 °C in the N group and 4.3 ± 1.5 °C in the N+S group; P=0.47). The corresponding body temperature reductions were 3.6 ± 1.2 °C and 4.6 ± 1.5 °C (P=0.1). The resuscitation outcome was similar in both groups. Mixed venous oxygen saturation was lower in the N group after cooling and rewarming (P=0.024 and 0.002, respectively) as compared with the N+S group. ICP was higher after rewarming in the N group (25.2 ± 2.9 mmHg; P=0.01) than in the N+S group (15.7 ± 3.3 mmHg). Conclusions: Intranasal balloon catheters can be used for therapeutic hypothermia initiation, maintenance and rewarming during CPR and after successful resuscitation in pigs.