Reversibly Switching the Function of a Surface between Attacking and Defending against Bacteria

Attack or defend! A smart polymer surface has two reversibly switchable equilibrium states, a cationic N,N‐dimethyl‐2‐morpholinone (CB‐Ring) and a zwitterionic carboxy betaine (CB‐OH). CB‐Ring will kill bacteria upon contact under dry conditions, whereas CB‐OH will release the previously attached an...

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Published inAngewandte Chemie (International ed.) Vol. 51; no. 11; pp. 2602 - 2605
Main Authors Cao, Zhiqiang, Mi, Luo, Mendiola, Jose, Ella-Menye, Jean-Rene, Zhang, Lei, Xue, Hong, Jiang, Shaoyi
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 12.03.2012
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Adhesion
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
antimicrobial activity
Bacteria
Bacteria - drug effects
Betaine - chemistry
Betaines
biological activity
Cationic
Cations - chemistry
Contact
Drying
Escherichia coli - drug effects
materials science
Morpholines - chemistry
Polymers - chemistry
Polymers - pharmacology
Resists
surface chemistry
Surface Properties
switchable materials
Switching
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Summary:Attack or defend! A smart polymer surface has two reversibly switchable equilibrium states, a cationic N,N‐dimethyl‐2‐morpholinone (CB‐Ring) and a zwitterionic carboxy betaine (CB‐OH). CB‐Ring will kill bacteria upon contact under dry conditions, whereas CB‐OH will release the previously attached and dead bacteria and further resist adhesion of bacteria under wet conditions.
Bibliography:Defense Threat Reduction Agency - No. HDTRA1-10-1-0074
Office of Naval Research - No. N000140910137
ark:/67375/WNG-B3F0QGF2-X
This work has been supported by the Defense Threat Reduction Agency (HDTRA1-10-1-0074) and the Office of Naval Research (N000140910137).
ArticleID:ANIE201106466
istex:38357EF07DB77F0022BF8F959B99FAAC61274CF2
This work has been supported by the Defense Threat Reduction Agency (HDTRA1‐10‐1‐0074) and the Office of Naval Research (N000140910137).
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201106466