Critical Review of Mouse Models of Venous Thrombosis

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 32; no. 3; pp. 556 - 562
• Main Authors: Diaz, Jose A, Obi, Andrea T, Myers, Daniel D, Wrobleski, Shirley K, Henke, Peter K, Mackman, Nigel, Wakefield, Thomas W
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.03.2012; Lippincott Williams & Wilkins
• Subjects: Animals; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blood. Blood coagulation. Reticuloendothelial system; Cardiology. Vascular system; Chlorides; Constriction; Disease Models, Animal; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Electrolysis; Ferric Compounds; Ligation; Medical sciences; Mice; Pharmacology. Drug treatments; Vena Cava, Inferior - pathology; Vena Cava, Inferior - physiopathology; Vena Cava, Inferior - surgery; Venous Thrombosis - blood; Venous Thrombosis - etiology; Venous Thrombosis - pathology; Venous Thrombosis - physiopathology; Venous Thrombosis - therapy; Animal model; animal models; Rodentia; Cardiovascular disease; vascular biology; Venous disease; Vascular disease; Vertebrata; Mammalia; thrombosis; Mouse; Animal; Atherosclerosis; Venous thrombosis

Deep vein thrombosis and pulmonary embolism are a significant health care concern, representing a major source of mortality and morbidity. In order to understand the pathophysiology of thrombogenesis and thrombus resolution, animal models are necessary. Mouse models of venous thrombosis contribute t...