Critical Review of Mouse Models of Venous Thrombosis

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 32; no. 3; pp. 556 - 562
• Main Authors: Diaz, Jose A, Obi, Andrea T, Myers, Daniel D, Wrobleski, Shirley K, Henke, Peter K, Mackman, Nigel, Wakefield, Thomas W
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.03.2012; Lippincott Williams & Wilkins
• Subjects: Animals; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blood. Blood coagulation. Reticuloendothelial system; Cardiology. Vascular system; Chlorides; Constriction; Disease Models, Animal; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Electrolysis; Ferric Compounds; Ligation; Medical sciences; Mice; Pharmacology. Drug treatments; Vena Cava, Inferior - pathology; Vena Cava, Inferior - physiopathology; Vena Cava, Inferior - surgery; Venous Thrombosis - blood; Venous Thrombosis - etiology; Venous Thrombosis - pathology; Venous Thrombosis - physiopathology; Venous Thrombosis - therapy; Animal model; animal models; Rodentia; Cardiovascular disease; vascular biology; Venous disease; Vascular disease; Vertebrata; Mammalia; thrombosis; Mouse; Animal; Atherosclerosis; Venous thrombosis
• ISSN: 1079-5642; 1524-4636
• DOI: 10.1161/ATVBAHA.111.244608

Deep vein thrombosis and pulmonary embolism are a significant health care concern, representing a major source of mortality and morbidity. In order to understand the pathophysiology of thrombogenesis and thrombus resolution, animal models are necessary. Mouse models of venous thrombosis contribute to our understanding of the initiation, propagation, and resolution of venous thrombus, as well as allow for the evaluation of new pharmaceutical approaches to prophylaxis and treatment of deep vein thrombosis. In this work we review the ferric chloride model, the inferior vena cava ligation model, the inferior vena cava stenosis models, and the electrolytic inferior vena cava model and compare their advantages and disadvantages.