The role of androgen and its related signals in PCOS

• Published in: Journal of cellular and molecular medicine Vol. 25; no. 4; pp. 1825 - 1837
• Main Authors: Ye, Wenting, Xie, Tingting, Song, Yali, Zhou, Lili
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2021; John Wiley and Sons Inc
• Subjects: Adrenal glands; androgen; Androgens; Biosynthesis; cell signal; Cholesterol; complication; Cytochrome; Dehydrogenases; Endocrine disorders; Enzymes; hyperandrogenism; Insulin; Kinases; Menstruation; Metabolism; Ovaries; Ovulation; PCOS; Physiology; Polycystic ovary syndrome; Proteins; Review; Reviews; Testosterone; PCOS; androgen; complication; cell signal; hyperandrogenism

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not been completely understood. Hyperandrogenism is an important clinic feature in patients with PCOS, suggesting its pathologic role in the develop...