The role of androgen and its related signals in PCOS

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not been completely understood. Hyperandrogenism is an important clinic feature in patients with PCOS, suggesting its pathologic role in the develop...

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Bibliographic Details
Published inJournal of cellular and molecular medicine Vol. 25; no. 4; pp. 1825 - 1837
Main Authors Ye, Wenting, Xie, Tingting, Song, Yali, Zhou, Lili
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.02.2021
John Wiley and Sons Inc
Subjects
Adrenal glands
androgen
Androgens
Biosynthesis
cell signal
Cholesterol
complication
Cytochrome
Dehydrogenases
Endocrine disorders
Enzymes
hyperandrogenism
Insulin
Kinases
Menstruation
Metabolism
Ovaries
Ovulation
PCOS
Physiology
Polycystic ovary syndrome
Proteins
Review
Reviews
Testosterone
PCOS
androgen
complication
cell signal
hyperandrogenism
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Summary:Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not been completely understood. Hyperandrogenism is an important clinic feature in patients with PCOS, suggesting its pathologic role in the development and progression of PCOS. However, the actual role of androgen and the related signals in PCOS and PCOS‐related complications have not yet been clarified. In this review, we surveyed the origin and effects of androgen on PCOS and the related complications, highlighted the cellular signals affecting androgen synthesis and summarized the pathological processes caused by hyperandrogenism. Our review well reveals the important mechanisms referring the pathogenesis of PCOS and provides important clues to the clinic strategies in patients with PCOS.
Bibliography:This work was supported by the National Key R&D Program of China (Grant No. 2020YFC2005000), National Natural Science Foundation of China (Grant Nos. 82070707, 91949114, 81722011 and 81521003), Frontier Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory (Grant No. 2018GZR110105004), Outstanding Scholar Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory (Grant No. 2018GZR110102004), and Innovation team of chronic kidney disease with integrated traditional Chinese and Western Medicine (2019KCXTD014).
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Funding information
Wenting Ye and Tingting Xie contributed equally to this work.
ISSN:1582-1838
1582-4934
1582-4934
DOI:10.1111/jcmm.16205