The role of androgen and its related signals in PCOS

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not been completely understood. Hyperandrogenism is an important clinic feature in patients with PCOS, suggesting its pathologic role in the develop...

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Published inJournal of cellular and molecular medicine Vol. 25; no. 4; pp. 1825 - 1837
Main Authors Ye, Wenting, Xie, Tingting, Song, Yali, Zhou, Lili
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.02.2021
John Wiley and Sons Inc
Subjects
Adrenal glands
androgen
Androgens
Biosynthesis
cell signal
Cholesterol
complication
Cytochrome
Dehydrogenases
Endocrine disorders
Enzymes
hyperandrogenism
Insulin
Kinases
Menstruation
Metabolism
Ovaries
Ovulation
PCOS
Physiology
Polycystic ovary syndrome
Proteins
Review
Reviews
Testosterone
PCOS
androgen
complication
cell signal
hyperandrogenism
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Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not been completely understood. Hyperandrogenism is an important clinic feature in patients with PCOS, suggesting its pathologic role in the development and progression of PCOS. However, the actual role of androgen and the related signals in PCOS and PCOS‐related complications have not yet been clarified. In this review, we surveyed the origin and effects of androgen on PCOS and the related complications, highlighted the cellular signals affecting androgen synthesis and summarized the pathological processes caused by hyperandrogenism. Our review well reveals the important mechanisms referring the pathogenesis of PCOS and provides important clues to the clinic strategies in patients with PCOS.
AbstractList Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not been completely understood. Hyperandrogenism is an important clinic feature in patients with PCOS, suggesting its pathologic role in the development and progression of PCOS. However, the actual role of androgen and the related signals in PCOS and PCOS‐related complications have not yet been clarified. In this review, we surveyed the origin and effects of androgen on PCOS and the related complications, highlighted the cellular signals affecting androgen synthesis and summarized the pathological processes caused by hyperandrogenism. Our review well reveals the important mechanisms referring the pathogenesis of PCOS and provides important clues to the clinic strategies in patients with PCOS.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not been completely understood. Hyperandrogenism is an important clinic feature in patients with PCOS, suggesting its pathologic role in the development and progression of PCOS. However, the actual role of androgen and the related signals in PCOS and PCOS-related complications have not yet been clarified. In this review, we surveyed the origin and effects of androgen on PCOS and the related complications, highlighted the cellular signals affecting androgen synthesis and summarized the pathological processes caused by hyperandrogenism. Our review well reveals the important mechanisms referring the pathogenesis of PCOS and provides important clues to the clinic strategies in patients with PCOS.Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not been completely understood. Hyperandrogenism is an important clinic feature in patients with PCOS, suggesting its pathologic role in the development and progression of PCOS. However, the actual role of androgen and the related signals in PCOS and PCOS-related complications have not yet been clarified. In this review, we surveyed the origin and effects of androgen on PCOS and the related complications, highlighted the cellular signals affecting androgen synthesis and summarized the pathological processes caused by hyperandrogenism. Our review well reveals the important mechanisms referring the pathogenesis of PCOS and provides important clues to the clinic strategies in patients with PCOS.
Author Xie, Tingting
Zhou, Lili
Ye, Wenting
Song, Yali
AuthorAffiliation 3 Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou China
1 Division of Nephrology State Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Nanfang Hospital Southern Medical University Guangzhou China
2 Center for Reproductive Medicine Department of Obstetrics and Gynecology Nanfang Hospital Southern Medical University Guangzhou China
AuthorAffiliation_xml – name: 1 Division of Nephrology State Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Nanfang Hospital Southern Medical University Guangzhou China
– name: 2 Center for Reproductive Medicine Department of Obstetrics and Gynecology Nanfang Hospital Southern Medical University Guangzhou China
– name: 3 Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou China
Author_xml – sequence: 1
  givenname: Wenting
  surname: Ye
  fullname: Ye, Wenting
  organization: Southern Medical University
– sequence: 2
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  surname: Xie
  fullname: Xie, Tingting
  organization: Southern Medical University
– sequence: 3
  givenname: Yali
  surname: Song
  fullname: Song, Yali
  email: syl@smu.edu.cn
  organization: Southern Medical University
– sequence: 4
  givenname: Lili
  orcidid: 0000-0001-5044-6965
  surname: Zhou
  fullname: Zhou, Lili
  email: jinli730@smu.edu.cn
  organization: Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33369146$$D View this record in MEDLINE/PubMed
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Issue 4
Keywords PCOS
androgen
complication
cell signal
hyperandrogenism
Language English
License Attribution
2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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Notes This work was supported by the National Key R&D Program of China (Grant No. 2020YFC2005000), National Natural Science Foundation of China (Grant Nos. 82070707, 91949114, 81722011 and 81521003), Frontier Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory (Grant No. 2018GZR110105004), Outstanding Scholar Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory (Grant No. 2018GZR110102004), and Innovation team of chronic kidney disease with integrated traditional Chinese and Western Medicine (2019KCXTD014).
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Funding information
Wenting Ye and Tingting Xie contributed equally to this work.
ORCID 0000-0001-5044-6965
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1111/jcmm.16205
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Snippet Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not...
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pubmed
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StartPage 1825
SubjectTerms Adrenal glands
androgen
Androgens
Biosynthesis
cell signal
Cholesterol
complication
Cytochrome
Dehydrogenases
Endocrine disorders
Enzymes
hyperandrogenism
Insulin
Kinases
Menstruation
Metabolism
Ovaries
Ovulation
PCOS
Physiology
Polycystic ovary syndrome
Proteins
Review
Reviews
Testosterone
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Title The role of androgen and its related signals in PCOS
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjcmm.16205
https://www.ncbi.nlm.nih.gov/pubmed/33369146
https://www.proquest.com/docview/2489133334
https://www.proquest.com/docview/2730557884
https://www.proquest.com/docview/2473407569
https://pubmed.ncbi.nlm.nih.gov/PMC7882969
Volume 25
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