MechanoAPI‐ILs: Pharmaceutical Ionic Liquids Obtained through Mechanochemical Synthesis

• Published in: ChemSusChem Vol. 10; no. 7; pp. 1360 - 1363
• Main Authors: Martins, Inês C. B., Oliveira, M. Conceição, Diogo, Hermínio P., Branco, Luís C., Duarte, M. Teresa
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 10.04.2017
• Subjects: Amines - chemical synthesis; Chemistry Techniques, Synthetic - methods; Cyclohexanecarboxylic Acids - chemical synthesis; gabapentin; gamma-Aminobutyric Acid - chemical synthesis; Glutamic Acid - chemical synthesis; Green Chemistry Technology - methods; Ionic liquids; Ionic Liquids - chemistry; Ions; l-glutamic acid; Liquids; Mechanical Phenomena; Mechanochemistry; pharmaceutical; Pharmaceuticals; Solid state; Solvents; Strategy; Synthesis; l-glutamic acid; pharmaceutical; mechanochemistry; ionic liquids; gabapentin
• ISSN: 1864-5631; 1864-564X
• DOI: 10.1002/cssc.201700153

An alternative, efficient, and green synthetic strategy for the preparation of pharmaceutical ionic liquids using mechanochemistry (MechanoAPI‐ILs) is reported. Six new API‐ILs based on gabapentin and l‐glutamic acid were successfully synthesized and characterized, demonstrating that mechanochemistry is a very promising synthetic strategy. Results compare both the new and the classical approach and clearly show the advantages of the new method. This new technique is faster, solvent free, reproducible, selective, and leads to higher yields. A solid state strategy: For the first time, mechanochemistry is used in the preparation of pharmaceutical ionic liquids (MechanoAPI‐ILs). Six new API‐ILs are successfully synthesized and characterized, demonstrating this to be a very promising synthetic strategy. The technique is faster, solvent free, reproducible, selective, and leads to higher yields compared to conventional processes