Additional copies of a 25 Mb chromosomal region originating from 17q23.1-17qter are present in 90% of high-grade neuroblastomas

• Published in: Genes chromosomes & cancer Vol. 17; no. 3; pp. 156 - 165
• Main Authors: Meddeb, Mounira, Danglot, Gisèle, Chudoba, Iise, Vénuat, Anne-Marie, Bénard, Jean, Avet-Loiseau, Hervé, Vasseur, Béatrice, Le Paslier, Denis, Terrier-Lacombe, Marie-Jose, Hartmann, Olivier, Bernheim, Alain
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.11.1996
• Subjects: Blotting, Southern; Bone Marrow Neoplasms - genetics; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Artificial, Yeast; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 17; Humans; In Situ Hybridization, Fluorescence; Lymphoma - genetics; Neuroblastoma - genetics; Prognosis
• ISSN: 1045-2257; 1098-2264
• DOI: 10.1002/(SICI)1098-2264(199611)17:3<156::AID-GCC3>3.0.CO;2-3

Neuroblastoma shows remarkable heterogeneity, ranging from spontaneous regression to progression toward highly malignant tumors. In search of genetic abnormalities that could explain this variability, we have characterized neuroblastoma tumors by using multiple fluorescent hybridizations. Our results indicate that chromosome 17 is rearranged very frequently in the form of unbalanced translocations with numerous chromosomal partners, all leading to the presence of supernumerary copies of a 25 Mb chromosomal region originating from 17q23.1‐qter. Additional 17q material was detected in more than 90% of untreated high‐grade neuroblastomas and, along with 1p36 deletion, should represent the most frequent genetic abnormality of neuroblastoma observed until now. Genes Chromosom Cancer 17:156–165 (1996). © 1996 Wiley‐Liss, Inc.