Risk assessment of rectal anastomotic leakage (RAREAL) after DIXON in non-emergency patients with rectal cancer

• Published in: BMC gastroenterology Vol. 23; no. 1; pp. 1 - 343
• Main Authors: Zheng, Xue-Cong, Su, Jin-Bo, Zheng, Jin-Jie
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 03.10.2023; BioMed Central; BMC
• Subjects: Abdomen; Anastomotic leak; Anastomotic leakage (AL); Cancer; Cancer patients; Cancer surgery; Colonoscopy; Colorectal cancer; DIXON; Electrolytes; Gastroenterology; Glycosylated hemoglobin; Health care expenditures; Hospitalization; Hospitals; Hypertension; Laparoscopy; Medical imaging; Oncology, Experimental; Ostomy; Patients; Rectal cancer; Rectum; Risk assessment; Risk assessment of rectal anastomotic leak (RAREAL); Risk factors; Statistical analysis; Surgeons; Surgical anastomosis; Taiwan
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-023-02982-2

Abstract Background The routine establishment of a diverting stoma (DS) remains controversial in every patient undergoing Dixon operation. We aimed to establish a model for the risk assessment of rectal anastomotic leak (RAREAL) after Dixon in non-emergency patients with rectal cancer, using routinely available variables, by which surgeons could individualize their approach to DS. Methods 323 patients who underwent Dixon operation for rectal cancer from January 2015 to December 2018 were taken as the model group for retrospective study. Univariable and multivariable logistic regression analysis was used to determine the independent risk factors associated with anastomotic leakage. We constructed the RAREAL model. 150 patients who underwent Dixon operation due to rectal cancer from January 2019 to December 2020 were collected according to the uniform criteria as a validation group to validate the RAREAL model. Results In the model group, multivariable analysis identified the following variables as independent risk factors for AL: HbA1c (odds ratio (OR) = 4.107; P  = 0.044), Left colic artery (LCA) non preservation (OR = 4.360; P  = 0.026), Tumor distance from the anal margin (TD) (OR = 6.373; P  = 0.002). In the model group, the area under the curve (AUC) of the receiver operating characteristic (ROC) for evaluating AL with RAREAL was 0.733, and when RAREAL score = 2.5, its sensitivity, specificity and Youden index were 0.385, 0.973, 0.358, respectively. The AUC was 0.722 in the validation group and its sensitivity and specificity were 0.333 and 0.985, respectively, when RAREAL score = 2.5. Conclusion The RAREAL score can be used to assess the risk of AL after Dixon operation for rectal cancer, and prophylactic DS should be proactively done when the score is greater than 2.5.