Hyperuricemia as a Risk Factor in Hypertension among Patients with Very High Cardiovascular Risk

• Published in: Healthcare (Basel) Vol. 11; no. 17; p. 2460
• Main Authors: Muszyński, Paweł, Dąbrowski, Emil Julian, Pasławska, Marta, Niwińska, Marta, Kurasz, Anna, Święczkowski, Michał, Tokarewicz, Justyna, Kuźma, Łukasz, Kożuch, Marcin, Dobrzycki, Sławomir
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2023; MDPI
• Subjects: Angina pectoris; Asymptomatic; Blood pressure; Cardiac arrhythmia; Cardiology; Cardiovascular disease; Care and treatment; Chronic obstructive pulmonary disease; complications; Complications and side effects; Coronary heart disease; Coronary vessels; Development and progression; Disease prevention; Heart attacks; Heart failure; Hypertension; Hyperuricemia; Ischemia; Kidney diseases; Prevention; Risk factors; Statistical analysis; Uric acid; Vein & artery diseases; Poland
• ISSN: 2227-9032; 2227-9032
• DOI: 10.3390/healthcare11172460

Hypertension remains a global threat to public health, affecting the worldwide population. It is one of the most common risk factors for cardiovascular disease. Today’s treatments focus on creating a hypotensive effect. However, there is a constant search for additional factors to reduce the potential of developing hypertension complications. These factors may act as a parallel treatment target with a beneficial effect in specific populations. Some studies suggest that uric acid may be considered such a factor. This study investigated the potential effect of uric acid concentrations over 5 mg/dL on the incidence of hypertension complications among patients with very high cardiovascular risk. A total of 705 patients with hypertension and very high cardiovascular risk were selected and included in the analysis. The patients were divided and compared according to serum uric acid levels. The study showed a higher occurrence of heart failure (OR = 1.7898; CI: 1.2738–2.5147; p = 0.0008), atrial fibrillation (OR = 3.4452; CI: 1.5414–7.7002; p = 0.0026) and chronic kidney disease (OR = 2.4470; CI: 1.3746–4.3558; p = 0.0024) among individuals with serum uric acid levels over 5 mg/dL, males and those with a BMI > 25 kg/m2. These findings suggest that even serum uric acid concentrations over 5 mg/dL may affect the prevalence of hypertension-related complications among patients with very high cardiovascular risk.