Mechanochemical synthesis of small organic molecules

• Published in: Beilstein journal of organic chemistry Vol. 13; no. 1; pp. 1907 - 1931
• Main Authors: Achar, Tapas Kumar, Bose, Anima, Mal, Prasenjit
• Format: Journal Article
• Language: English
• Published: Germany Beilstein-Institut zur Föerderung der Chemischen Wissenschaften 11.09.2017; Beilstein-Institut
• Subjects: Alternative energy sources; ball-milling; Carbon; Chemical reactions; Chemistry; Chemists; Energy resources; Global warming; green chemistry; Ligands; mechanochemistry; Review; solid-phase synthesis; solvent-free synthesis; Sonication; ball-milling; mechanochemistry; green chemistry; solid-phase synthesis; solvent-free synthesis
• ISSN: 1860-5397; 2195-951X; 1860-5397
• DOI: 10.3762/bjoc.13.186

With the growing interest in renewable energy and global warming, it is important to minimize the usage of hazardous chemicals in both academic and industrial research, elimination of waste, and possibly recycle them to obtain better results in greener fashion. The studies under the area of mechanochemistry which cover the grinding chemistry to ball milling, sonication, etc. are certainly of interest to the researchers working on the development of green methodologies. In this review, a collection of examples on recent developments in organic bond formation reactions like carbon-carbon (C-C), carbon-nitrogen (C-N), carbon-oxygen (C-O), carbon-halogen (C-X), etc. is documented. Mechanochemical syntheses of heterocyclic rings, multicomponent reactions and organometallic molecules including their catalytic applications are also highlighted.