Novel adhesive mineral-organic bone cements based on phosphoserine and magnesium phosphates or oxides

• Published in: Journal of materials science. Materials in medicine Vol. 34; no. 4; p. 14
• Main Authors: Renner, Tobias, Otto, Paul, Kübler, Alexander C., Hölscher-Doht, Stefanie, Gbureck, Uwe
• Format: Journal Article
• Language: English
• Published: New York Springer US 24.03.2023; Springer Nature B.V; Springer
• Subjects: Adhesive strength; Adhesives; Biomaterials; Biomaterials Synthesis and Characterization; Biomedical Engineering and Bioengineering; Biomedical materials; Bonding strength; Bone cements; Bone Cements - chemistry; Calcium phosphates; Calcium Phosphates - chemistry; Ceramics; Chemistry and Materials Science; Composites; Electron microscopy; Glass; Infrared analysis; Infrared spectroscopy; Magnesium; Magnesium phosphate; Materials Science; Materials Testing; Mechanical tests; Microscopy, Electron, Scanning; Minerals; Natural Materials; Oxides; Phosphates; Phosphoserine; Polymer Sciences; Regenerative Medicine/Tissue Engineering; Surfaces and Interfaces; Tetracalcium phosphate; Thin Films; Tricalcium phosphate; X-ray diffraction
• ISSN: 1573-4838; 0957-4530; 1573-4838
• DOI: 10.1007/s10856-023-06714-6

Present surgical situations require a bone adhesive which has not yet been developed for use in clinical applications. Recently, phosphoserine modified cements (PMC) based on mixtures of o-phosphoserine (OPLS) and calcium phosphates, such as tetracalcium phosphate (TTCP) or α-tricalcium phosphate (α-TCP) as well as chelate setting magnesium phosphate cements have gained increasing popularity for their use as mineral bone adhesives. Here, we investigated new mineral-organic bone cements based on phosphoserine and magnesium phosphates or oxides, which possess excellent adhesive properties. These were analyzed by X-ray diffraction, Fourier infrared spectroscopy and electron microscopy and subjected to mechanical tests to determine the bond strength to bone after ageing at physiological conditions. The novel biomineral adhesives demonstrate excellent bond strength to bone with approximately 6.6–7.3 MPa under shear load. The adhesives are also promising due to their cohesive failure pattern and ductile character. In this context, the new adhesive cements are superior to currently prevailing bone adhesives. Future efforts on bone adhesives made from phosphoserine and Mg 2+ appear to be very worthwhile. Graphical Abstract