Gestational vitamin D deficiency and autism spectrum disorder

• Published in: BJPsych open Vol. 3; no. 2; pp. 85 - 90
• Main Authors: Vinkhuyzen, Anna A. E., Eyles, Darryl W., Burne, Thomas H. J., Blanken, Laura M. E., Kruithof, Claudia J., Verhulst, Frank, White, Tonya, Jaddoe, Vincent W., Tiemeier, Henning, McGrath, John J.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.03.2017; The Royal College of Psychiatrists
• Subjects: Autism; Vitamin D; Vitamin deficiency
• ISSN: 2056-4724; 2056-4724
• DOI: 10.1192/bjpo.bp.116.004077

There is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs). The association between vitamin D deficiency during gestation, a critical period in neurodevelopment, and ASD is not well understood. To determine the association between gestational vitamin D status and ASD. Based on a birth cohort ( =4334), we examined the association between 25-hydroxyvitamin D (25OHD), assessed from both maternal mid-gestation sera and neonatal sera, and ASD (defined by clinical records; =68 cases). Individuals in the 25OHD-deficient group at mid-gestation had more than twofold increased risk of ASD (odds ratio (OR)=2.42, 95% confidence interval (CI) 1.09 to 5.07, =0.03) compared with the sufficient group. The findings persisted in analyses including children of European ethnicity only. Mid-gestational vitamin D deficiency was associated with an increased risk of ASD. Because gestational vitamin D deficiency is readily preventable with safe, inexpensive and readily available supplementation, this risk factor warrants closer scrutiny. None. © The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.