Effects of in vitro Amitriptyline, Fluoxetine, Tranylcypromine and Venlafaxine on Saphenous Vein Grafts

• Published in: Revista brasileira de cirurgia cardiovascular Vol. 34; no. 3; pp. 290 - 296
• Main Authors: Akinci, Melek, Karadag, Cetin Hakan, Huseyin, Serhat, Oltulu, Cagatay, Canbaz, Suat, Gunduz, Ozgur, Topuz, Ruhan Deniz
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Sociedade Brasileira de Cirurgia Cardiovascular 01.01.2019
• Subjects: Aged; Aged, 80 and over; Amitriptyline; Amitriptyline - pharmacology; Analysis of Variance; Antidepressants; Antidepressive Agents - pharmacology; CARDIAC & CARDIOVASCULAR SYSTEMS; Cardiology; Cardiovascular disease; Coronary Artery Bypass - methods; Coronary vessels; Endothelium; Endothelium, Vascular - drug effects; Female; Fluoxetine; Fluoxetine - pharmacology; Heart surgery; Humans; Internet; Male; Middle Aged; Mortality; Muscle, Smooth, Vascular - drug effects; Original; Reference Values; Saphenous Vein; Saphenous Vein - drug effects; Saphenous Vein - transplantation; Serotonin; Smooth muscle; SURGERY; Transplants - drug effects; Tranylcypromine; Tranylcypromine - pharmacology; Variance analysis; Vasodilation - drug effects; Venlafaxine; Venlafaxine Hydrochloride - pharmacology; Turkey; Venlafaxine; Amitriptyline; Saphenous Vein; Tranylcypromine; Fluoxetine
• ISSN: 1678-9741; 0102-7638; 1678-9741
• DOI: 10.21470/1678-9741-2018-0338

In this study, we aimed to examine the effects of amitriptyline, fluoxetine, tranylcypromine and venlafaxine on saphenous vein grafts in coronary artery bypass graft surgeries. 59 patients (40 males and 19 females; mean age 65.1 years, distribution: 45-84 years) who had coronary artery bypass graft surgery between February 2014 and May 2016 were included in the study. After the saphenous vein grafts with intact and denuded endothelium were precontracted with 3×10-6M phenylephrine, amitriptyline, fluoxetine and tranylcypromine were cumulatively added to isolated organ baths in the range of 10-11-3x10-5M, while venlafaxine was added in the range of 10-9-3×10-5M. Then, the antidepressant-induced relaxation responses were recorded isometrically. While the relaxation response of amitriptyline at -6.42 (Log M) was 74.6%, the response at -6.32 (Log M) was 75.5%. While the relaxation response at -6.46 (Log M) of fluoxetine was 68.02%, the response at -6.02 (Log M) was 72.12%. While the relaxation response of tranylcypromine at -7.53 (Log M) was 61.13%, the response at -7.23 (Log M) was 65.53%. While the relaxation response of venlafaxine at -6.21 (Log M) was 29.98%, the response at -5.90 (Log M) was 32.96%. The maximum relaxation at minimum and maximum therapeutic concentrations was obtained with amitriptyline, fluoxetine and tranylcypromine, and the minimum relaxation was obtained with venlafaxine. The relaxation responses were independent of the endothelium.