Stress–strain curve and elastic behavior of the fibrotic lung with usual interstitial pneumonia pattern during protective mechanical ventilation

• Published in: Scientific reports Vol. 14; no. 1; pp. 13158 - 13
• Main Authors: Tonelli, Roberto, Rizzoni, Raffaella, Grasso, Salvatore, Cortegiani, Andrea, Ball, Lorenzo, Samarelli, Anna Valeria, Fantini, Riccardo, Bruzzi, Giulia, Tabbì, Luca, Cerri, Stefania, Manicardi, Linda, Andrisani, Dario, Gozzi, Filippo, Castaniere, Ivana, Smit, Marry R., Paulus, Frederique, Bos, Lieuwe D. J., Clini, Enrico, Marchioni, Alessandro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.06.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308; 692/699/1785; 692/699/1785/3193; Aged; Body mass index; Collagen; Deformation; Elasticity; Elastin; Extracellular matrix; Female; Fibrosis; Humanities and Social Sciences; Humans; Idiopathic pulmonary fibrosis; Interstitial lung disease; Lung - pathology; Lung - physiopathology; Lung Diseases, Interstitial - physiopathology; Lung elastance; Lung fibrosis; Lungs; Male; Mathematical models; Mechanical ventilation; Mechanics; Middle Aged; Models, Theoretical; multidisciplinary; Parenchyma; Pneumonia; Pulmonary Fibrosis - metabolism; Pulmonary Fibrosis - physiopathology; Respiration; Respiration, Artificial - adverse effects; Respiratory distress syndrome; Respiratory Distress Syndrome - physiopathology; Respiratory Mechanics - physiology; Science; Science (multidisciplinary); Strain; Stress; Stress, Mechanical; Stress-strain curves; Ventilation; Ventilator-Induced Lung Injury - physiopathology; Acute respiratory distress syndrome; Usual interstitial pneumonia; Lung elastance; Idiopathic pulmonary fibrosis; Specific elastance; Respiratory mechanics; End-inspiratory transpulmonary pressure; Ventilator-induced lung injury; Interstitial lung disease; Lung fibrosis; Stress; Strain; Transpulmonary pressure; Invasive mechanical ventilation; End-expiratory transpulmonary pressure; Acute respiratory failure
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-63670-z

Patients with acute exacerbation of lung fibrosis with usual interstitial pneumonia (EUIP) pattern are at increased risk for ventilator-induced lung injury (VILI) and mortality when exposed to mechanical ventilation (MV). Yet, lack of a mechanical model describing UIP-lung deformation during MV represents a research gap. Aim of this study was to develop a constitutive mathematical model for UIP-lung deformation during lung protective MV based on the stress–strain behavior and the specific elastance of patients with EUIP as compared to that of acute respiratory distress syndrome (ARDS) and healthy lung. Partitioned lung and chest wall mechanics were assessed for patients with EUIP and primary ARDS (1:1 matched based on body mass index and PaO 2 /FiO 2 ratio) during a PEEP trial performed within 24 h from intubation. Patient’s stress–strain curve and the lung specific elastance were computed and compared with those of healthy lungs, derived from literature. Respiratory mechanics were used to fit a novel mathematical model of the lung describing mechanical-inflation-induced lung parenchyma deformation, differentiating the contributions of elastin and collagen, the main components of lung extracellular matrix. Five patients with EUIP and 5 matched with primary ARDS were included and analyzed. Global strain was not different at low PEEP between the groups. Overall specific elastance was significantly higher in EUIP as compared to ARDS (28.9 [22.8–33.2] cmH 2 O versus 11.4 [10.3–14.6] cmH 2 O, respectively). Compared to ARDS and healthy lung, the stress/strain curve of EUIP showed a steeper increase, crossing the VILI threshold stress risk for strain values greater than 0.55. The contribution of elastin was prevalent at lower strains, while the contribution of collagen was prevalent at large strains. The stress/strain curve for collagen showed an upward shift passing from ARDS and healthy lungs to EUIP lungs. During MV, patients with EUIP showed different respiratory mechanics, stress–strain curve and specific elastance as compared to ARDS patients and healthy subjects and may experience VILI even when protective MV is applied. According to our mathematical model of lung deformation during mechanical inflation, the elastic response of UIP-lung is peculiar and different from ARDS. Our data suggest that patients with EUIP experience VILI with ventilatory setting that are lung-protective for patients with ARDS.