LncRNA UCA1 promotes keratinocyte-driven inflammation via suppressing METTL14 and activating the HIF-1α/NF-κB axis in psoriasis

• Published in: Cell death & disease Vol. 14; no. 4; pp. 279 - 12
• Main Authors: Hu, Yibo, Lei, Li, Jiang, Ling, Zeng, Hongliang, Zhang, Yushan, Fu, Chuhan, Guo, Haoran, Dong, Yumeng, Ouyang, Yujie, Zhang, Xiaolin, Huang, Jinhua, Zeng, Qinghai, Chen, Jing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.04.2023; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/1; 13/109; 13/21; 13/51; 13/89; 14/32; 14/34; 45/90; 45/91; 631/250/262/2106/2518; 631/337/176/2016; 692/699/249/1313/1758; 82/58; Antibodies; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell Proliferation; Cytokines; Cytokines - metabolism; Endothelial cells; Endothelial Cells - metabolism; Gene expression; Humans; Hypoxia-inducible factor 1a; Immunology; Inflammation; Inflammation - genetics; Inflammation - metabolism; Innate immunity; Keratinocytes; Keratinocytes - metabolism; Life Sciences; Methyltransferase; Methyltransferases - metabolism; Molecular modelling; N6-methyladenosine; NF-kappa B - genetics; NF-kappa B - metabolism; NF-κB protein; Non-coding RNA; Proteomes; Psoriasis; Psoriasis - pathology; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Signal transduction; Stat3 protein; Transcriptomes

Keratinocytes are closely associated with innate immunity and inflammatory responses, and are dysregulated during the development of psoriasis, but the underlying mechanisms are not yet fully understood. This work aims to reveal the effects of long non-coding RNA (lncRNA) UCA1 in psoriatic keratinoc...