Vascular endothelium is the basic way for stem cells to treat erectile dysfunction: a bibliometric study

• Published in: Cell death discovery Vol. 9; no. 1; p. 143
• Main Authors: Zou, Hede, Zhang, Xuesong, Chen, Wenkang, Tao, Yi, Li, Bolin, Liu, Hanfei, Wang, Ruikun, Zhao, Jiayou
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2023; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/532/489; 692/420/256; Apoptosis; Bibliometrics; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Diabetes mellitus; Endothelial cells; Endothelium; Erectile dysfunction; Fibrosis; Life Sciences; Mesenchymal stem cells; Oxidative stress; Prostatectomy; Review; Review Article; Smooth muscle; Stem Cells; Vascular endothelial growth factor
• ISSN: 2058-7716; 2058-7716
• DOI: 10.1038/s41420-023-01443-9

Vascular endothelial is considered to be a key factor in the pathogenesis of erectile dysfunction (ED). The purpose is to reveal the research trend of the field of ED and vascular endothelium. In addition, the goal is to discover the role and mechanism of vascular endothelium in ED. Bibliometrics and visualization methods based on CiteSpace were selected. We conducted the co-authorship analysis of countries, institutions and authors, co-occurrence analysis of keywords, and co-citation analysis of literature and authors through CiteSpace 6.1.R3. 1431 articles from Web of Science Core Collection (WOSCC) were included in the analysis from 1991 to 2022. We found some influential and cutting-edge nodes in each map, including countries, institutions, authors, articles, etc. Stem cell, therapy, oxidative stress, cavernous nerve injury, radical prostatectomy, fibrosis, erectile function, mesenchymal stem cell, and apoptosis may be hot keywords. In conclusion, the efficacy and mechanisms of stem cells and their derivatives in the treatment of diabetes (DM) ED and cavernous nerve injury (CNI) ED are the future research trends. Stem cells therapy for ED is a hot spot in this field, which side notes that stem cells may work mainly through improving endothelial function. Vascular endothelial cells and VEGF may repair nerve and cavernous smooth muscle directly or indirectly, and finally polish up erectile function.