First-night effect reduces the beneficial effects of sleep on visual plasticity and modifies the underlying neurochemical processes

• Published in: Scientific reports Vol. 14; no. 1; pp. 14388 - 14
• Main Authors: Tamaki, Masako, Yamada, Takashi, Barnes-Diana, Tyler, Wang, Zhiyan, Watanabe, Takeo, Sasaki, Yuka
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.06.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378; 631/477; Adult; Brain - physiology; Brain research; Comorbidity; Confounding (Statistics); Female; Humanities and Social Sciences; Humans; Latency; Learning - physiology; Magnetic Resonance Spectroscopy; Male; multidisciplinary; Neuronal Plasticity; Neuroplasticity; Performance assessment; Plasticity; Polysomnography; Science; Science (multidisciplinary); Sleep; Sleep - physiology; Sleep disorders; Spectrum analysis; Visual discrimination learning; Visual Perception - physiology; Visual plasticity; Young Adult; Young adults
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-64091-8

Individuals experience difficulty falling asleep in a new environment, termed the first night effect (FNE). However, the impact of the FNE on sleep-induced brain plasticity remains unclear. Here, using a within-subject design, we found that the FNE significantly reduces visual plasticity during sleep in young adults. Sleep-onset latency (SOL), an indicator of the FNE, was significantly longer during the first sleep session than the second session, confirming the FNE. We assessed performance gains in visual perceptual learning after sleep and increases in the excitatory-to-inhibitory neurotransmitter (E/I) ratio in early visual areas during sleep using magnetic resonance spectroscopy and polysomnography. These parameters were significantly smaller in sleep with the FNE than in sleep without the FNE; however, these parameters were not correlated with SOL. These results suggest that while the neural mechanisms of the FNE and brain plasticity are independent, sleep disturbances temporarily block the neurochemical process fundamental for brain plasticity.