Laquinimod suppress antigen presentation in relapsing–remitting multiple sclerosis: In-vitro high-throughput gene expression study
Laquinimod (LAQ) is a new immunomodulatory drug shown to be effective in the treatment of relapsing–remitting multiple sclerosis (RRMS); however, its molecular target pathways are not well recognized. In this study we characterized in-vitro the molecular effects of LAQ in peripheral blood mononuclea...
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| Published in | Journal of neuroimmunology Vol. 221; no. 1; pp. 87 - 94 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
15.04.2010
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| Abstract | Laquinimod (LAQ) is a new immunomodulatory drug shown to be effective in the treatment of relapsing–remitting multiple sclerosis (RRMS); however, its molecular target pathways are not well recognized. In this study we characterized in-vitro the molecular effects of LAQ in peripheral blood mononuclear cells (PBMC) of healthy subjects and RRMS patients by gene expression microarrays. We demonstrated that LAQ induced suppression of genes related to antigen presentation and corresponding inflammatory pathways. These findings were demonstrated mainly via the NFkB pathway. Analysis of PBMC subpopulations identified activation of Th2 response in CD14+ and CD4+ cells and suppression of proliferation in CD8+ cells. |
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| AbstractList | Laquinimod (LAQ) is a new immunomodulatory drug shown to be effective in the treatment of relapsing-remitting multiple sclerosis (RRMS); however, its molecular target pathways are not well recognized. In this study we characterized in-vitro the molecular effects of LAQ in peripheral blood mononuclear cells (PBMC) of healthy subjects and RRMS patients by gene expression microarrays. We demonstrated that LAQ induced suppression of genes related to antigen presentation and corresponding inflammatory pathways. These findings were demonstrated mainly via the NFkB pathway. Analysis of PBMC subpopulations identified activation of Th2 response in CD14+ and CD4+ cells and suppression of proliferation in CD8+ cells. Abstract Laquinimod (LAQ) is a new immunomodulatory drug shown to be effective in the treatment of relapsing–remitting multiple sclerosis (RRMS); however, its molecular target pathways are not well recognized. In this study we characterized in-vitro the molecular effects of LAQ in peripheral blood mononuclear cells (PBMC) of healthy subjects and RRMS patients by gene expression microarrays. We demonstrated that LAQ induced suppression of genes related to antigen presentation and corresponding inflammatory pathways. These findings were demonstrated mainly via the NFkB pathway. Analysis of PBMC subpopulations identified activation of Th2 response in CD14+ and CD4+ cells and suppression of proliferation in CD8+ cells. Laquinimod (LAQ) is a new immunomodulatory drug shown to be effective in the treatment of relapsing-remitting multiple sclerosis (RRMS); however, its molecular target pathways are not well recognized. In this study we characterized in-vitro the molecular effects of LAQ in peripheral blood mononuclear cells (PBMC) of healthy subjects and RRMS patients by gene expression microarrays. We demonstrated that LAQ induced suppression of genes related to antigen presentation and corresponding inflammatory pathways. These findings were demonstrated mainly via the NFkB pathway. Analysis of PBMC subpopulations identified activation of Th2 response in CD14+ and CD4+ cells and suppression of proliferation in CD8+ cells.Laquinimod (LAQ) is a new immunomodulatory drug shown to be effective in the treatment of relapsing-remitting multiple sclerosis (RRMS); however, its molecular target pathways are not well recognized. In this study we characterized in-vitro the molecular effects of LAQ in peripheral blood mononuclear cells (PBMC) of healthy subjects and RRMS patients by gene expression microarrays. We demonstrated that LAQ induced suppression of genes related to antigen presentation and corresponding inflammatory pathways. These findings were demonstrated mainly via the NFkB pathway. Analysis of PBMC subpopulations identified activation of Th2 response in CD14+ and CD4+ cells and suppression of proliferation in CD8+ cells. |
| Author | Tuller, T. Gritzman, T. Feldman, A. Gurevich, M. Achiron, A. Orbach, R. |
| Author_xml | – sequence: 1 givenname: M. surname: Gurevich fullname: Gurevich, M. email: gurevich@sheba.health.gov.il – sequence: 2 givenname: T. surname: Gritzman fullname: Gritzman, T. – sequence: 3 givenname: R. surname: Orbach fullname: Orbach, R. – sequence: 4 givenname: T. surname: Tuller fullname: Tuller, T. – sequence: 5 givenname: A. surname: Feldman fullname: Feldman, A. – sequence: 6 givenname: A. surname: Achiron fullname: Achiron, A. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20347159$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.cell.2008.01.020 10.1016/j.clim.2007.07.002 10.1074/jbc.272.23.15036 10.1016/j.jneuroim.2004.02.016 10.1016/S0140-6736(08)60918-6 10.1074/jbc.M410725200 10.1016/j.biochi.2008.04.010 10.4049/jimmunol.176.12.7346 10.1016/S0074-7742(07)79004-9 10.1212/01.WNL.0000154520.48391.69 10.1126/science.282.5386.121 10.1074/jbc.M204990200 10.1073/pnas.94.20.10838 10.1073/pnas.97.18.10138 10.1002/jlb.64.4.503 10.1007/400_2009_22 10.1182/blood-2006-11-059980 10.4049/jimmunol.168.5.2475 10.1038/sj.onc.1203647 10.1093/clinchem/45.1.7 10.1146/annurev.immunol.20.091301.131133 10.1038/ni1355 10.1016/j.jneuroim.2004.01.013 10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V 10.1093/oxfordjournals.jbchem.a021773 10.1038/nm872 10.1007/s10254-003-0015-z 10.1016/j.molimm.2005.08.004 10.1016/S0028-3908(02)00015-1 10.1182/blood-2007-11-121111 10.1016/S1534-5807(04)00137-6 10.1074/jbc.271.6.2935 10.1097/00001756-200108280-00010 10.1016/S0952-7915(96)80012-4 10.4049/jimmunol.161.9.4599 10.1007/0-387-24180-9_5 10.1378/chest.117.4.1162 10.1016/j.brainres.2007.01.099 10.1016/j.molimm.2004.07.014 10.1038/90609 10.4049/jimmunol.170.8.4189 10.1177/135245850000600103 10.1038/sj.cdd.4401850 10.1196/annals.1381.017 10.4049/jimmunol.169.5.2712 10.1016/j.autrev.2006.02.009 10.1016/1074-7613(95)90081-0 10.2353/ajpath.2006.050284 10.1038/ng1561 10.1016/j.molimm.2007.05.003 10.1016/S0165-5728(02)00225-4 10.1172/JCI9012 10.1126/science.1129594 10.1038/nri1570 10.1084/jem.191.11.1869 10.1111/j.1365-2567.2007.02694.x 10.1101/gad.12.14.2120 10.1016/j.micinf.2004.03.007 10.1074/jbc.M301569200 10.1016/S0167-5699(00)01596-6 10.1046/j.1365-2567.2002.01430.x 10.1146/annurev.immunol.23.021704.115526 10.1146/annurev.immunol.14.1.649 |
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| Keywords | Microarray gene expression Multiple sclerosis Laquinimod PBMC Cell subpopulation |
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| References | Sano, Kuroki (bib48) 2005; 42 Verbsky, Randolph, Shornick, Chaplin (bib57) 2002; 168 Polman, Barkhof, Sandberg-Wollheim, Linde, Nordle, Nederman (bib44) 2005; 64 Borron, Crouch, Lewis, Wright, Possmayer, Fraher (bib7) 1998; 161 Stoeckle, Tolosa (bib52) 2009 Fierro, Pedraza-Alva, Rosenstein (bib20) 2006; 176 Parham (bib42) 2005; 5 Kishore, Greenhough, Waters, Shrive, Ghai, Kamran, Bernal, Reid, Madan, Chakraborty (bib31) 2006; 43 Csiszar, Ahmad, Smith, Labinskyy, Gao, Kaley, Edwards, Wolin, Ungvari (bib14) 2006; 168 Xiao, Ghosh (bib60) 2005; 560 Stanley, Berg, Einstein, Lee, Pixley, Wang, Yeung (bib50) 1997; 46 Kawai, Akira (bib30) 2006; 13 Leone, DeGregori, Yan, Jakoi, Ishida, Williams, Nevins (bib34) 1998; 12 Hayden, Ghosh (bib23) 2008; 132 Okoye, Krishnan, Chandok, Tsokos, Farber (bib40) 2007; 125 Johnson, Suidan, McDole, Pirko (bib27) 2007; 79 Duits, Ravensbergen, Rademaker, Hiemstra, Nibbering (bib19) 2002; 106 Chen, Castranova, Shi, Demers (bib11) 1999; 45 Strack, Caligiuri, Pelletier, Boisclair, Theodoras, Beer-Romero, Glass, Parsons, Copeland, Auger, Benfield, Brizuela, Rolfe (bib53) 2000; 19 Gruber, Fresser, Jenny, Uberall, Leitges, Baier (bib21) 2008; 45 Chertov, Michiel, Xu, Wang, Tani, Murphy, Longo, Taub, Oppenheim (bib12) 1996; 271 Opal, DePalo (bib41) 2000; 117 Achour, M'Bika, Baudouin, Caruelle, Courty (bib3) 2008; 90 Sage (bib47) 2004; 6 Teixeira, Cardoso, Souza, Teixeira (bib55) 2004; 150 Bai, Liu, Liu, Guo, Cox, Wen, Zheng, Liu (bib5) 2000; 105 Segal, Friedman, Kaminski, Regev, Koller (bib49) 2005; 37 Kaneko, Nimmerjahn, Ravetch (bib29) 2006; 313 Achiron, Gurevich (bib1) 2006; 5 Randolph, Bierl, Isaacson (bib45) 2007; 1144 Moretta, Biassoni, Bottino, Mingari, Moretta (bib38) 2000; 21 Krishnan, Warke, Nambiar, Tsokos, Farber (bib32) 2003; 170 Kabashima, Sakata, Nagamachi, Miyachi, Inaba, Narumiya (bib28) 2003; 9 Imai, Baba, Nishimura, Kakizaki, Takagi, Yoshie (bib24) 1997; 272 Stenger, Hanson, Teitelbaum, Dewan, Niazi, Froelich, Ganz, Thoma-Uszynski, Melian, Bogdan, Porcelli, Bloom, Krensky, Modlin (bib51) 1998; 282 Achiron, Feldman, Mandel, Gurevich (bib2) 2007; 1107 Paul, Gottmann, Lessmann (bib43) 2001; 12 Johnson, Bromley, Dustin, Thomas (bib26) 2000; 97 Brunmark, Runstrom, Ohlsson, Sparre, Brodin, Astrom, Hedlund (bib8) 2002; 130 Caristi, Piraino, Cucinotta, Valenti, Loddo, Teti (bib9) 2005; 280 Dong, Davis, Flavell (bib18) 2002; 20 Chang, Steelman, Shelton, Lee, Navolanic, Blalock, Franklin, McCubrey (bib10) 2003; 22 Izawa, Ishimaru, Moriyama, Kohashi, Arakaki, Hayashi (bib25) 2007; 110 Takada, Toriyama, Muramatsu, Song, Torii, Muramatsu (bib54) 1997; 122 DiMeo, Tian, Zhang, Narushima, Berg (bib17) 2008; 123 Del Valle, Engel, Martin (bib16) 2003; 278 Hanada, Kinjyo, Inagaki-Ohara, Yoshimura (bib22) 2003; 149 Baldwin (bib6) 1996; 14 Akira, Takeda, Kaisho (bib4) 2001; 2 Vanderlugt, Miller (bib56) 1996; 8 Roos, Schilder-Tol, Weening, Aten (bib46) 1998; 64 Comi, Pulizzi, Rovaris, Abramsky, Arbizu, Boiko, Gold, Havrdova, Komoly, Selmaj, Sharrack, Filippi (bib13) 2008; 371 Menzies-Gow, Ying, Sabroe, Stubbs, Soler, Williams, Kay (bib36) 2002; 169 Noben-Trauth, Shultz, Brombacher, Urban, Gu, Paul (bib39) 1997; 94 Wang, Chen (bib59) 2004; 6 Zou, Abbas, Volkmann, Nennesmo, Levi, Wahren, Winblad, Hedlund, Zhu (bib64) 2002; 42 Yamashita, Katsumata, Iwashima, Kimura, Shimizu, Kamata, Shin, Seki, Suzuki, Taniguchi, Nakayama (bib61) 2000; 191 Zhang, Baker, Kolson, Rostami (bib63) 2000; 6 Letschka, Kollmann, Pfeifhofer-Obermair, Lutz-Nicoladoni, Obermair, Fresser, Leitges, Hermann-Kleiter, Kaminski, Baier (bib35) 2008; 112 de Bruyn, Rangarajan, Reedquist, Figdor, Bos (bib15) 2002; 277 Lanier (bib33) 2005; 23 Minami, Nakagawa, Kawahara, Miyazaki, Sada, Yamamura, Taniguchi (bib37) 1995; 2 Wan, Chi, Xie, Schneider, Flavell (bib58) 2006; 7 Yang, Xu, Xiao, Hedlund, Link (bib62) 2004; 156 Yamashita (10.1016/j.jneuroim.2010.02.010_bib61) 2000; 191 Roos (10.1016/j.jneuroim.2010.02.010_bib46) 1998; 64 Kaneko (10.1016/j.jneuroim.2010.02.010_bib29) 2006; 313 Randolph (10.1016/j.jneuroim.2010.02.010_bib45) 2007; 1144 Achiron (10.1016/j.jneuroim.2010.02.010_bib2) 2007; 1107 Comi (10.1016/j.jneuroim.2010.02.010_bib13) 2008; 371 Lanier (10.1016/j.jneuroim.2010.02.010_bib33) 2005; 23 Borron (10.1016/j.jneuroim.2010.02.010_bib7) 1998; 161 de Bruyn (10.1016/j.jneuroim.2010.02.010_bib15) 2002; 277 Achiron (10.1016/j.jneuroim.2010.02.010_bib1) 2006; 5 Sano (10.1016/j.jneuroim.2010.02.010_bib48) 2005; 42 Fierro (10.1016/j.jneuroim.2010.02.010_bib20) 2006; 176 Caristi (10.1016/j.jneuroim.2010.02.010_bib9) 2005; 280 Moretta (10.1016/j.jneuroim.2010.02.010_bib38) 2000; 21 Akira (10.1016/j.jneuroim.2010.02.010_bib4) 2001; 2 Del Valle (10.1016/j.jneuroim.2010.02.010_bib16) 2003; 278 Johnson (10.1016/j.jneuroim.2010.02.010_bib27) 2007; 79 Takada (10.1016/j.jneuroim.2010.02.010_bib54) 1997; 122 Baldwin (10.1016/j.jneuroim.2010.02.010_bib6) 1996; 14 Xiao (10.1016/j.jneuroim.2010.02.010_bib60) 2005; 560 Sage (10.1016/j.jneuroim.2010.02.010_bib47) 2004; 6 DiMeo (10.1016/j.jneuroim.2010.02.010_bib17) 2008; 123 Zhang (10.1016/j.jneuroim.2010.02.010_bib63) 2000; 6 Segal (10.1016/j.jneuroim.2010.02.010_bib49) 2005; 37 Brunmark (10.1016/j.jneuroim.2010.02.010_bib8) 2002; 130 Teixeira (10.1016/j.jneuroim.2010.02.010_bib55) 2004; 150 Wan (10.1016/j.jneuroim.2010.02.010_bib58) 2006; 7 Verbsky (10.1016/j.jneuroim.2010.02.010_bib57) 2002; 168 Hayden (10.1016/j.jneuroim.2010.02.010_bib23) 2008; 132 Krishnan (10.1016/j.jneuroim.2010.02.010_bib32) 2003; 170 Duits (10.1016/j.jneuroim.2010.02.010_bib19) 2002; 106 Parham (10.1016/j.jneuroim.2010.02.010_bib42) 2005; 5 Paul (10.1016/j.jneuroim.2010.02.010_bib43) 2001; 12 Opal (10.1016/j.jneuroim.2010.02.010_bib41) 2000; 117 Zou (10.1016/j.jneuroim.2010.02.010_bib64) 2002; 42 Letschka (10.1016/j.jneuroim.2010.02.010_bib35) 2008; 112 Bai (10.1016/j.jneuroim.2010.02.010_bib5) 2000; 105 Johnson (10.1016/j.jneuroim.2010.02.010_bib26) 2000; 97 Stenger (10.1016/j.jneuroim.2010.02.010_bib51) 1998; 282 Chertov (10.1016/j.jneuroim.2010.02.010_bib12) 1996; 271 Csiszar (10.1016/j.jneuroim.2010.02.010_bib14) 2006; 168 Yang (10.1016/j.jneuroim.2010.02.010_bib62) 2004; 156 Kishore (10.1016/j.jneuroim.2010.02.010_bib31) 2006; 43 Dong (10.1016/j.jneuroim.2010.02.010_bib18) 2002; 20 Chen (10.1016/j.jneuroim.2010.02.010_bib11) 1999; 45 Achour (10.1016/j.jneuroim.2010.02.010_bib3) 2008; 90 Kabashima (10.1016/j.jneuroim.2010.02.010_bib28) 2003; 9 Leone (10.1016/j.jneuroim.2010.02.010_bib34) 1998; 12 Chang (10.1016/j.jneuroim.2010.02.010_bib10) 2003; 22 Imai (10.1016/j.jneuroim.2010.02.010_bib24) 1997; 272 Noben-Trauth (10.1016/j.jneuroim.2010.02.010_bib39) 1997; 94 Minami (10.1016/j.jneuroim.2010.02.010_bib37) 1995; 2 Stanley (10.1016/j.jneuroim.2010.02.010_bib50) 1997; 46 Strack (10.1016/j.jneuroim.2010.02.010_bib53) 2000; 19 Okoye (10.1016/j.jneuroim.2010.02.010_bib40) 2007; 125 Izawa (10.1016/j.jneuroim.2010.02.010_bib25) 2007; 110 Stoeckle (10.1016/j.jneuroim.2010.02.010_bib52) 2009 Vanderlugt (10.1016/j.jneuroim.2010.02.010_bib56) 1996; 8 Polman (10.1016/j.jneuroim.2010.02.010_bib44) 2005; 64 Menzies-Gow (10.1016/j.jneuroim.2010.02.010_bib36) 2002; 169 Wang (10.1016/j.jneuroim.2010.02.010_bib59) 2004; 6 Hanada (10.1016/j.jneuroim.2010.02.010_bib22) 2003; 149 Kawai (10.1016/j.jneuroim.2010.02.010_bib30) 2006; 13 Gruber (10.1016/j.jneuroim.2010.02.010_bib21) 2008; 45 |
| References_xml | – volume: 12 start-page: 2635 year: 2001 end-page: 2639 ident: bib43 article-title: NT-3 regulates BDNF-induced modulation of synaptic transmission in cultured hippocampal neurons publication-title: Neuroreport – volume: 560 start-page: 41 year: 2005 end-page: 45 ident: bib60 article-title: NF-kappaB, an evolutionarily conserved mediator of immune and inflammatory responses publication-title: Adv. Exp. Med. Biol. – volume: 130 start-page: 163 year: 2002 end-page: 172 ident: bib8 article-title: The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis publication-title: J. Neuroimmunol. – volume: 42 start-page: 731 year: 2002 end-page: 739 ident: bib64 article-title: Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissue publication-title: Neuropharmacology – volume: 278 start-page: 17430 year: 2003 end-page: 17437 ident: bib16 article-title: The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2) publication-title: J. Biol. Chem. – volume: 149 start-page: 72 year: 2003 end-page: 86 ident: bib22 article-title: Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases publication-title: Rev. Physiol. Biochem. Pharmacol. – volume: 132 start-page: 344 year: 2008 end-page: 362 ident: bib23 article-title: Shared principles in NF-kappaB signaling publication-title: Cell – volume: 105 start-page: 1227 year: 2000 end-page: 1232 ident: bib5 article-title: The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis publication-title: J. Clin. Invest. – volume: 9 start-page: 744 year: 2003 end-page: 749 ident: bib28 article-title: Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells publication-title: Nat. Med. – volume: 170 start-page: 4189 year: 2003 end-page: 4195 ident: bib32 article-title: The FcR gamma subunit and Syk kinase replace the CD3 zeta-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells publication-title: J. Immunol. – volume: 45 start-page: 117 year: 2008 end-page: 126 ident: bib21 article-title: PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes publication-title: Mol. Immunol. – volume: 5 start-page: 517 year: 2006 end-page: 522 ident: bib1 article-title: Peripheral blood gene expression signature mirrors central nervous system disease: the model of multiple sclerosis publication-title: Autoimmun. Rev. – volume: 122 start-page: 453 year: 1997 end-page: 458 ident: bib54 article-title: Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses: chemotactic activity to neutrophils and association with inflammatory synovitis publication-title: J. Biochem. – volume: 8 start-page: 831 year: 1996 end-page: 836 ident: bib56 article-title: Epitope spreading publication-title: Curr. Opin. Immunol. – volume: 64 start-page: 503 year: 1998 end-page: 510 ident: bib46 article-title: Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment publication-title: J. Leukoc. Biol. – volume: 191 start-page: 1869 year: 2000 end-page: 1879 ident: bib61 article-title: T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex publication-title: J. Exp. Med. – volume: 110 start-page: 242 year: 2007 end-page: 250 ident: bib25 article-title: Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance publication-title: Blood – volume: 277 start-page: 29468 year: 2002 end-page: 29476 ident: bib15 article-title: The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion publication-title: J. Biol. Chem. – volume: 46 start-page: 4 year: 1997 end-page: 10 ident: bib50 article-title: Biology and action of colony-stimulating factor-1 publication-title: Mol. Reprod. Dev. – volume: 14 start-page: 649 year: 1996 end-page: 683 ident: bib6 article-title: The NF-kappa B and I kappa B proteins: new discoveries and insights publication-title: Annu. Rev. Immunol. – volume: 112 start-page: 4617 year: 2008 end-page: 4627 ident: bib35 article-title: PKC-theta selectively controls the adhesion-stimulating molecule Rap1 publication-title: Blood – volume: 79 start-page: 73 year: 2007 end-page: 97 ident: bib27 article-title: The CD8 T cell in multiple sclerosis: suppressor cell or mediator of neuropathology? publication-title: Int. Rev. Neurobiol. – volume: 2 start-page: 675 year: 2001 end-page: 680 ident: bib4 article-title: Toll-like receptors: critical proteins linking innate and acquired immunity publication-title: Nat. Immunol. – volume: 42 start-page: 279 year: 2005 end-page: 287 ident: bib48 article-title: The lung collectins, SP-A and SP-D, modulate pulmonary innate immunity publication-title: Mol. Immunol. – volume: 37 start-page: S38 year: 2005 end-page: S45 ident: bib49 article-title: From signatures to models: understanding cancer using microarrays publication-title: Nat. Genet. – volume: 6 start-page: 3 year: 2000 end-page: 13 ident: bib63 article-title: Chemokines and chemokine receptors in the pathogenesis of multiple sclerosis publication-title: Mult. Scler. – volume: 125 start-page: 5 year: 2007 end-page: 15 ident: bib40 article-title: Proximal signaling control of human effector CD4 T cell function publication-title: Clin. Immunol. – volume: 5 start-page: 201 year: 2005 end-page: 214 ident: bib42 article-title: MHC class I molecules and KIRs in human history, health and survival publication-title: Nat. Rev. Immunol. – volume: 6 start-page: 607 year: 2004 end-page: 608 ident: bib47 article-title: Cyclin C makes an entry into the cell cycle publication-title: Dev. Cell – volume: 22 start-page: 469 year: 2003 end-page: 480 ident: bib10 article-title: Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review) publication-title: Int. J. Oncol. – volume: 271 start-page: 2935 year: 1996 end-page: 2940 ident: bib12 article-title: Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils publication-title: J. Biol. Chem. – volume: 94 start-page: 10838 year: 1997 end-page: 10843 ident: bib39 article-title: An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 168 start-page: 629 year: 2006 end-page: 638 ident: bib14 article-title: Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype publication-title: Am. J. Pathol. – volume: 272 start-page: 15036 year: 1997 end-page: 15042 ident: bib24 article-title: The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4 publication-title: J. Biol. Chem. – volume: 6 start-page: 759 year: 2004 end-page: 766 ident: bib59 article-title: Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses publication-title: Microbes Infect. – year: 2009 ident: bib52 article-title: Antigen processing and presentation in multiple sclerosis publication-title: Results Probl. Cell Differ. – volume: 1107 start-page: 155 year: 2007 end-page: 167 ident: bib2 article-title: Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse publication-title: Ann. N.Y. Acad. Sci. – volume: 123 start-page: 250 year: 2008 end-page: 262 ident: bib17 article-title: Increased interleukin-10 production and Th2 skewing in the absence of 5-lipoxygenase publication-title: Immunology – volume: 90 start-page: 1791 year: 2008 end-page: 1795 ident: bib3 article-title: Pleiotrophin induces expression of inflammatory cytokines in peripheral blood mononuclear cells publication-title: Biochimie – volume: 168 start-page: 2475 year: 2002 end-page: 2482 ident: bib57 article-title: Nonhematopoietic expression of Janus kinase 3 is required for efficient recruitment of Th2 lymphocytes and eosinophils in OVA-induced airway inflammation publication-title: J. Immunol. – volume: 19 start-page: 3529 year: 2000 end-page: 3536 ident: bib53 article-title: SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4 publication-title: Oncogene – volume: 2 start-page: 89 year: 1995 end-page: 100 ident: bib37 article-title: Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway publication-title: Immunity – volume: 117 start-page: 1162 year: 2000 end-page: 1172 ident: bib41 article-title: Anti-inflammatory cytokines publication-title: Chest – volume: 156 start-page: 3 year: 2004 end-page: 9 ident: bib62 article-title: Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats publication-title: J. Neuroimmunol. – volume: 313 start-page: 670 year: 2006 end-page: 673 ident: bib29 article-title: Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation publication-title: Science – volume: 176 start-page: 7346 year: 2006 end-page: 7353 ident: bib20 article-title: TCR-dependent cell response is modulated by the timing of CD43 engagement publication-title: J. Immunol. – volume: 371 start-page: 2085 year: 2008 end-page: 2092 ident: bib13 article-title: Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study publication-title: Lancet – volume: 13 start-page: 816 year: 2006 end-page: 825 ident: bib30 article-title: TLR signaling publication-title: Cell Death Differ. – volume: 169 start-page: 2712 year: 2002 end-page: 2718 ident: bib36 article-title: Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers publication-title: J. Immunol. – volume: 64 start-page: 987 year: 2005 end-page: 991 ident: bib44 article-title: Treatment with laquinimod reduces development of active MRI lesions in relapsing MS publication-title: Neurology – volume: 97 start-page: 10138 year: 2000 end-page: 10143 ident: bib26 article-title: A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 161 start-page: 4599 year: 1998 end-page: 4603 ident: bib7 article-title: Recombinant rat surfactant-associated protein D inhibits human T lymphocyte proliferation and IL-2 production publication-title: J. Immunol. – volume: 45 start-page: 7 year: 1999 end-page: 17 ident: bib11 article-title: New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases publication-title: Clin. Chem. – volume: 12 start-page: 2120 year: 1998 end-page: 2130 ident: bib34 article-title: E2F3 activity is regulated during the cell cycle and is required for the induction of S phase publication-title: Genes Dev. – volume: 106 start-page: 517 year: 2002 end-page: 525 ident: bib19 article-title: Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells publication-title: Immunology – volume: 282 start-page: 121 year: 1998 end-page: 125 ident: bib51 article-title: An antimicrobial activity of cytolytic T cells mediated by granulysin publication-title: Science – volume: 280 start-page: 14433 year: 2005 end-page: 14442 ident: bib9 article-title: Prostaglandin E2 induces interleukin-8 gene transcription by activating C/EBP homologous protein in human T lymphocytes publication-title: J. Biol. Chem. – volume: 23 start-page: 225 year: 2005 end-page: 274 ident: bib33 article-title: NK cell recognition publication-title: Annu. Rev. Immunol. – volume: 21 start-page: 228 year: 2000 end-page: 234 ident: bib38 article-title: Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis publication-title: Immunol. Today – volume: 43 start-page: 1293 year: 2006 end-page: 1315 ident: bib31 article-title: Surfactant proteins SP-A and SP-D: structure, function and receptors publication-title: Mol. Immunol. – volume: 150 start-page: 157 year: 2004 end-page: 162 ident: bib55 article-title: Increased serum concentrations of monokine induced by interferon-gamma/CXCL9 and interferon-gamma-inducible protein 10/CXCL-10 in Sydenham's chorea patients publication-title: J. Neuroimmunol. – volume: 7 start-page: 851 year: 2006 end-page: 858 ident: bib58 article-title: The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function publication-title: Nat. Immunol. – volume: 20 start-page: 55 year: 2002 end-page: 72 ident: bib18 article-title: MAP kinases in the immune response publication-title: Annu. Rev. Immunol. – volume: 1144 start-page: 59 year: 2007 end-page: 69 ident: bib45 article-title: Regulation of NGF and NT-3 protein expression in peripheral targets by sympathetic input publication-title: Brain Res. – volume: 132 start-page: 344 year: 2008 ident: 10.1016/j.jneuroim.2010.02.010_bib23 article-title: Shared principles in NF-kappaB signaling publication-title: Cell doi: 10.1016/j.cell.2008.01.020 – volume: 125 start-page: 5 year: 2007 ident: 10.1016/j.jneuroim.2010.02.010_bib40 article-title: Proximal signaling control of human effector CD4 T cell function publication-title: Clin. Immunol. doi: 10.1016/j.clim.2007.07.002 – volume: 272 start-page: 15036 year: 1997 ident: 10.1016/j.jneuroim.2010.02.010_bib24 article-title: The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4 publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.23.15036 – volume: 156 start-page: 3 year: 2004 ident: 10.1016/j.jneuroim.2010.02.010_bib62 article-title: Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2004.02.016 – volume: 371 start-page: 2085 year: 2008 ident: 10.1016/j.jneuroim.2010.02.010_bib13 article-title: Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study publication-title: Lancet doi: 10.1016/S0140-6736(08)60918-6 – volume: 280 start-page: 14433 year: 2005 ident: 10.1016/j.jneuroim.2010.02.010_bib9 article-title: Prostaglandin E2 induces interleukin-8 gene transcription by activating C/EBP homologous protein in human T lymphocytes publication-title: J. Biol. Chem. doi: 10.1074/jbc.M410725200 – volume: 90 start-page: 1791 year: 2008 ident: 10.1016/j.jneuroim.2010.02.010_bib3 article-title: Pleiotrophin induces expression of inflammatory cytokines in peripheral blood mononuclear cells publication-title: Biochimie doi: 10.1016/j.biochi.2008.04.010 – volume: 176 start-page: 7346 year: 2006 ident: 10.1016/j.jneuroim.2010.02.010_bib20 article-title: TCR-dependent cell response is modulated by the timing of CD43 engagement publication-title: J. Immunol. doi: 10.4049/jimmunol.176.12.7346 – volume: 79 start-page: 73 year: 2007 ident: 10.1016/j.jneuroim.2010.02.010_bib27 article-title: The CD8 T cell in multiple sclerosis: suppressor cell or mediator of neuropathology? publication-title: Int. Rev. Neurobiol. doi: 10.1016/S0074-7742(07)79004-9 – volume: 64 start-page: 987 year: 2005 ident: 10.1016/j.jneuroim.2010.02.010_bib44 article-title: Treatment with laquinimod reduces development of active MRI lesions in relapsing MS publication-title: Neurology doi: 10.1212/01.WNL.0000154520.48391.69 – volume: 282 start-page: 121 year: 1998 ident: 10.1016/j.jneuroim.2010.02.010_bib51 article-title: An antimicrobial activity of cytolytic T cells mediated by granulysin publication-title: Science doi: 10.1126/science.282.5386.121 – volume: 277 start-page: 29468 year: 2002 ident: 10.1016/j.jneuroim.2010.02.010_bib15 article-title: The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion publication-title: J. Biol. Chem. doi: 10.1074/jbc.M204990200 – volume: 94 start-page: 10838 year: 1997 ident: 10.1016/j.jneuroim.2010.02.010_bib39 article-title: An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.94.20.10838 – volume: 97 start-page: 10138 year: 2000 ident: 10.1016/j.jneuroim.2010.02.010_bib26 article-title: A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.97.18.10138 – volume: 64 start-page: 503 year: 1998 ident: 10.1016/j.jneuroim.2010.02.010_bib46 article-title: Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment publication-title: J. Leukoc. Biol. doi: 10.1002/jlb.64.4.503 – year: 2009 ident: 10.1016/j.jneuroim.2010.02.010_bib52 article-title: Antigen processing and presentation in multiple sclerosis publication-title: Results Probl. Cell Differ. doi: 10.1007/400_2009_22 – volume: 110 start-page: 242 year: 2007 ident: 10.1016/j.jneuroim.2010.02.010_bib25 article-title: Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance publication-title: Blood doi: 10.1182/blood-2006-11-059980 – volume: 168 start-page: 2475 year: 2002 ident: 10.1016/j.jneuroim.2010.02.010_bib57 article-title: Nonhematopoietic expression of Janus kinase 3 is required for efficient recruitment of Th2 lymphocytes and eosinophils in OVA-induced airway inflammation publication-title: J. Immunol. doi: 10.4049/jimmunol.168.5.2475 – volume: 19 start-page: 3529 year: 2000 ident: 10.1016/j.jneuroim.2010.02.010_bib53 article-title: SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4 publication-title: Oncogene doi: 10.1038/sj.onc.1203647 – volume: 45 start-page: 7 year: 1999 ident: 10.1016/j.jneuroim.2010.02.010_bib11 article-title: New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases publication-title: Clin. Chem. doi: 10.1093/clinchem/45.1.7 – volume: 20 start-page: 55 year: 2002 ident: 10.1016/j.jneuroim.2010.02.010_bib18 article-title: MAP kinases in the immune response publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.20.091301.131133 – volume: 7 start-page: 851 year: 2006 ident: 10.1016/j.jneuroim.2010.02.010_bib58 article-title: The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function publication-title: Nat. Immunol. doi: 10.1038/ni1355 – volume: 150 start-page: 157 year: 2004 ident: 10.1016/j.jneuroim.2010.02.010_bib55 article-title: Increased serum concentrations of monokine induced by interferon-gamma/CXCL9 and interferon-gamma-inducible protein 10/CXCL-10 in Sydenham's chorea patients publication-title: J. Neuroimmunol. doi: 10.1016/j.jneuroim.2004.01.013 – volume: 46 start-page: 4 year: 1997 ident: 10.1016/j.jneuroim.2010.02.010_bib50 article-title: Biology and action of colony-stimulating factor-1 publication-title: Mol. Reprod. Dev. doi: 10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V – volume: 122 start-page: 453 year: 1997 ident: 10.1016/j.jneuroim.2010.02.010_bib54 article-title: Midkine, a retinoic acid-inducible heparin-binding cytokine in inflammatory responses: chemotactic activity to neutrophils and association with inflammatory synovitis publication-title: J. Biochem. doi: 10.1093/oxfordjournals.jbchem.a021773 – volume: 9 start-page: 744 year: 2003 ident: 10.1016/j.jneuroim.2010.02.010_bib28 article-title: Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells publication-title: Nat. Med. doi: 10.1038/nm872 – volume: 149 start-page: 72 year: 2003 ident: 10.1016/j.jneuroim.2010.02.010_bib22 article-title: Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases publication-title: Rev. Physiol. Biochem. Pharmacol. doi: 10.1007/s10254-003-0015-z – volume: 43 start-page: 1293 year: 2006 ident: 10.1016/j.jneuroim.2010.02.010_bib31 article-title: Surfactant proteins SP-A and SP-D: structure, function and receptors publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2005.08.004 – volume: 42 start-page: 731 year: 2002 ident: 10.1016/j.jneuroim.2010.02.010_bib64 article-title: Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissue publication-title: Neuropharmacology doi: 10.1016/S0028-3908(02)00015-1 – volume: 112 start-page: 4617 year: 2008 ident: 10.1016/j.jneuroim.2010.02.010_bib35 article-title: PKC-theta selectively controls the adhesion-stimulating molecule Rap1 publication-title: Blood doi: 10.1182/blood-2007-11-121111 – volume: 6 start-page: 607 year: 2004 ident: 10.1016/j.jneuroim.2010.02.010_bib47 article-title: Cyclin C makes an entry into the cell cycle publication-title: Dev. Cell doi: 10.1016/S1534-5807(04)00137-6 – volume: 271 start-page: 2935 year: 1996 ident: 10.1016/j.jneuroim.2010.02.010_bib12 article-title: Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.6.2935 – volume: 12 start-page: 2635 year: 2001 ident: 10.1016/j.jneuroim.2010.02.010_bib43 article-title: NT-3 regulates BDNF-induced modulation of synaptic transmission in cultured hippocampal neurons publication-title: Neuroreport doi: 10.1097/00001756-200108280-00010 – volume: 8 start-page: 831 year: 1996 ident: 10.1016/j.jneuroim.2010.02.010_bib56 article-title: Epitope spreading publication-title: Curr. Opin. Immunol. doi: 10.1016/S0952-7915(96)80012-4 – volume: 161 start-page: 4599 year: 1998 ident: 10.1016/j.jneuroim.2010.02.010_bib7 article-title: Recombinant rat surfactant-associated protein D inhibits human T lymphocyte proliferation and IL-2 production publication-title: J. Immunol. doi: 10.4049/jimmunol.161.9.4599 – volume: 560 start-page: 41 year: 2005 ident: 10.1016/j.jneuroim.2010.02.010_bib60 article-title: NF-kappaB, an evolutionarily conserved mediator of immune and inflammatory responses publication-title: Adv. Exp. Med. Biol. doi: 10.1007/0-387-24180-9_5 – volume: 117 start-page: 1162 year: 2000 ident: 10.1016/j.jneuroim.2010.02.010_bib41 article-title: Anti-inflammatory cytokines publication-title: Chest doi: 10.1378/chest.117.4.1162 – volume: 1144 start-page: 59 year: 2007 ident: 10.1016/j.jneuroim.2010.02.010_bib45 article-title: Regulation of NGF and NT-3 protein expression in peripheral targets by sympathetic input publication-title: Brain Res. doi: 10.1016/j.brainres.2007.01.099 – volume: 42 start-page: 279 year: 2005 ident: 10.1016/j.jneuroim.2010.02.010_bib48 article-title: The lung collectins, SP-A and SP-D, modulate pulmonary innate immunity publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2004.07.014 – volume: 2 start-page: 675 year: 2001 ident: 10.1016/j.jneuroim.2010.02.010_bib4 article-title: Toll-like receptors: critical proteins linking innate and acquired immunity publication-title: Nat. Immunol. doi: 10.1038/90609 – volume: 170 start-page: 4189 year: 2003 ident: 10.1016/j.jneuroim.2010.02.010_bib32 article-title: The FcR gamma subunit and Syk kinase replace the CD3 zeta-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells publication-title: J. Immunol. doi: 10.4049/jimmunol.170.8.4189 – volume: 6 start-page: 3 year: 2000 ident: 10.1016/j.jneuroim.2010.02.010_bib63 article-title: Chemokines and chemokine receptors in the pathogenesis of multiple sclerosis publication-title: Mult. Scler. doi: 10.1177/135245850000600103 – volume: 13 start-page: 816 year: 2006 ident: 10.1016/j.jneuroim.2010.02.010_bib30 article-title: TLR signaling publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4401850 – volume: 1107 start-page: 155 year: 2007 ident: 10.1016/j.jneuroim.2010.02.010_bib2 article-title: Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse publication-title: Ann. N.Y. Acad. Sci. doi: 10.1196/annals.1381.017 – volume: 22 start-page: 469 year: 2003 ident: 10.1016/j.jneuroim.2010.02.010_bib10 article-title: Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review) publication-title: Int. J. Oncol. – volume: 169 start-page: 2712 year: 2002 ident: 10.1016/j.jneuroim.2010.02.010_bib36 article-title: Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers publication-title: J. Immunol. doi: 10.4049/jimmunol.169.5.2712 – volume: 5 start-page: 517 year: 2006 ident: 10.1016/j.jneuroim.2010.02.010_bib1 article-title: Peripheral blood gene expression signature mirrors central nervous system disease: the model of multiple sclerosis publication-title: Autoimmun. Rev. doi: 10.1016/j.autrev.2006.02.009 – volume: 2 start-page: 89 year: 1995 ident: 10.1016/j.jneuroim.2010.02.010_bib37 article-title: Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway publication-title: Immunity doi: 10.1016/1074-7613(95)90081-0 – volume: 168 start-page: 629 year: 2006 ident: 10.1016/j.jneuroim.2010.02.010_bib14 article-title: Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2006.050284 – volume: 37 start-page: S38 year: 2005 ident: 10.1016/j.jneuroim.2010.02.010_bib49 article-title: From signatures to models: understanding cancer using microarrays publication-title: Nat. Genet. doi: 10.1038/ng1561 – volume: 45 start-page: 117 year: 2008 ident: 10.1016/j.jneuroim.2010.02.010_bib21 article-title: PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2007.05.003 – volume: 130 start-page: 163 year: 2002 ident: 10.1016/j.jneuroim.2010.02.010_bib8 article-title: The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis publication-title: J. Neuroimmunol. doi: 10.1016/S0165-5728(02)00225-4 – volume: 105 start-page: 1227 year: 2000 ident: 10.1016/j.jneuroim.2010.02.010_bib5 article-title: The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis publication-title: J. Clin. Invest. doi: 10.1172/JCI9012 – volume: 313 start-page: 670 year: 2006 ident: 10.1016/j.jneuroim.2010.02.010_bib29 article-title: Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation publication-title: Science doi: 10.1126/science.1129594 – volume: 5 start-page: 201 year: 2005 ident: 10.1016/j.jneuroim.2010.02.010_bib42 article-title: MHC class I molecules and KIRs in human history, health and survival publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1570 – volume: 191 start-page: 1869 year: 2000 ident: 10.1016/j.jneuroim.2010.02.010_bib61 article-title: T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex publication-title: J. Exp. Med. doi: 10.1084/jem.191.11.1869 – volume: 123 start-page: 250 year: 2008 ident: 10.1016/j.jneuroim.2010.02.010_bib17 article-title: Increased interleukin-10 production and Th2 skewing in the absence of 5-lipoxygenase publication-title: Immunology doi: 10.1111/j.1365-2567.2007.02694.x – volume: 12 start-page: 2120 year: 1998 ident: 10.1016/j.jneuroim.2010.02.010_bib34 article-title: E2F3 activity is regulated during the cell cycle and is required for the induction of S phase publication-title: Genes Dev. doi: 10.1101/gad.12.14.2120 – volume: 6 start-page: 759 year: 2004 ident: 10.1016/j.jneuroim.2010.02.010_bib59 article-title: Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses publication-title: Microbes Infect. doi: 10.1016/j.micinf.2004.03.007 – volume: 278 start-page: 17430 year: 2003 ident: 10.1016/j.jneuroim.2010.02.010_bib16 article-title: The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2) publication-title: J. Biol. Chem. doi: 10.1074/jbc.M301569200 – volume: 21 start-page: 228 year: 2000 ident: 10.1016/j.jneuroim.2010.02.010_bib38 article-title: Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis publication-title: Immunol. Today doi: 10.1016/S0167-5699(00)01596-6 – volume: 106 start-page: 517 year: 2002 ident: 10.1016/j.jneuroim.2010.02.010_bib19 article-title: Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells publication-title: Immunology doi: 10.1046/j.1365-2567.2002.01430.x – volume: 23 start-page: 225 year: 2005 ident: 10.1016/j.jneuroim.2010.02.010_bib33 article-title: NK cell recognition publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.23.021704.115526 – volume: 14 start-page: 649 year: 1996 ident: 10.1016/j.jneuroim.2010.02.010_bib6 article-title: The NF-kappa B and I kappa B proteins: new discoveries and insights publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.14.1.649 |
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| Snippet | Laquinimod (LAQ) is a new immunomodulatory drug shown to be effective in the treatment of relapsing–remitting multiple sclerosis (RRMS); however, its molecular... Abstract Laquinimod (LAQ) is a new immunomodulatory drug shown to be effective in the treatment of relapsing–remitting multiple sclerosis (RRMS); however, its... Laquinimod (LAQ) is a new immunomodulatory drug shown to be effective in the treatment of relapsing-remitting multiple sclerosis (RRMS); however, its molecular... |
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| SubjectTerms | Adult Allergy and Immunology Antigen Presentation - drug effects Antigens, CD - metabolism Cell subpopulation Cell Survival Dose-Response Relationship, Drug Female Gene Expression Profiling - methods Gene Expression Regulation - drug effects Humans Immunologic Factors - pharmacology Killer Cells, Natural - drug effects Laquinimod Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Microarray gene expression Middle Aged Models, Immunological Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - immunology Multiple Sclerosis, Relapsing-Remitting - pathology Neurology NF-kappaB-Inducing Kinase Oligonucleotide Array Sequence Analysis - methods PBMC Protein Array Analysis - methods Protein Serine-Threonine Kinases - metabolism Quinolones - pharmacology |
| Title | Laquinimod suppress antigen presentation in relapsing–remitting multiple sclerosis: In-vitro high-throughput gene expression study |
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