Novel Epigenetic Regulation of Alpha-Synuclein Expression in Down Syndrome

• Published in: Molecular neurobiology Vol. 53; no. 1; pp. 155 - 162
• Main Authors: Ramakrishna, Narayan, Meeker, Harry C., Brown, W. Ted
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2016; Springer Nature B.V
• Subjects: alpha-Synuclein - metabolism; Animals; Biomedical and Life Sciences; Biomedicine; Catechin - analogs & derivatives; Catechin - pharmacology; Cell Biology; Disease Models, Animal; DNA methylation; DNA Methylation - drug effects; Down syndrome; Down Syndrome - drug therapy; Down Syndrome - metabolism; Epigenesis, Genetic - drug effects; Epigenesis, Genetic - physiology; Epigenetics; Gene expression; Mice; Neurobiology; Neurology; Neurosciences; Promoter Regions, Genetic; Proteins; Demethylation; Down syndrome; EGCG; Alpha-synuclein; Ts65Dn mice

Alpha-synuclein ( SNCA ), a presynaptic protein, is significantly reduced in individuals with Down syndrome (DS) and Ts65Dn mice, a mouse model of DS. Methylation analyses of promoter proximal CpG sites indicate similar reduction in Ts65Dn mice compared to control mice. Epigallocatechin-3-gallate (E...