Novel Epigenetic Regulation of Alpha-Synuclein Expression in Down Syndrome

Alpha-synuclein ( SNCA ), a presynaptic protein, is significantly reduced in individuals with Down syndrome (DS) and Ts65Dn mice, a mouse model of DS. Methylation analyses of promoter proximal CpG sites indicate similar reduction in Ts65Dn mice compared to control mice. Epigallocatechin-3-gallate (E...

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Bibliographic Details
Published inMolecular neurobiology Vol. 53; no. 1; pp. 155 - 162
Main Authors Ramakrishna, Narayan, Meeker, Harry C., Brown, W. Ted
Format Journal Article
LanguageEnglish
Published New York Springer US 01.01.2016
Springer Nature B.V
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