Novel Epigenetic Regulation of Alpha-Synuclein Expression in Down Syndrome
Alpha-synuclein ( SNCA ), a presynaptic protein, is significantly reduced in individuals with Down syndrome (DS) and Ts65Dn mice, a mouse model of DS. Methylation analyses of promoter proximal CpG sites indicate similar reduction in Ts65Dn mice compared to control mice. Epigallocatechin-3-gallate (E...
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Published in | Molecular neurobiology Vol. 53; no. 1; pp. 155 - 162 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.01.2016
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Alpha-synuclein (
SNCA
), a presynaptic protein, is significantly reduced in individuals with Down syndrome (DS) and Ts65Dn mice, a mouse model of DS. Methylation analyses of promoter proximal CpG sites indicate similar reduction in Ts65Dn mice compared to control mice. Epigallocatechin-3-gallate (EGCG), a polyphenolic catechin present in green tea extract, increases methylation of
SNCA
promoter proximal CpG sites and expression in Ts65Dn mice. These results suggest a positive link between CpG methylation and
SNCA
expression in Down syndrome. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0893-7648 1559-1182 |
DOI: | 10.1007/s12035-014-8979-z |