Novel Epigenetic Regulation of Alpha-Synuclein Expression in Down Syndrome

Alpha-synuclein ( SNCA ), a presynaptic protein, is significantly reduced in individuals with Down syndrome (DS) and Ts65Dn mice, a mouse model of DS. Methylation analyses of promoter proximal CpG sites indicate similar reduction in Ts65Dn mice compared to control mice. Epigallocatechin-3-gallate (E...

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Published inMolecular neurobiology Vol. 53; no. 1; pp. 155 - 162
Main Authors Ramakrishna, Narayan, Meeker, Harry C., Brown, W. Ted
Format Journal Article
LanguageEnglish
Published New York Springer US 01.01.2016
Springer Nature B.V
Subjects
alpha-Synuclein - metabolism
Animals
Biomedical and Life Sciences
Biomedicine
Catechin - analogs & derivatives
Catechin - pharmacology
Cell Biology
Disease Models, Animal
DNA methylation
DNA Methylation - drug effects
Down syndrome
Down Syndrome - drug therapy
Down Syndrome - metabolism
Epigenesis, Genetic - drug effects
Epigenesis, Genetic - physiology
Epigenetics
Gene expression
Mice
Neurobiology
Neurology
Neurosciences
Promoter Regions, Genetic
Proteins
Demethylation
Down syndrome
EGCG
Alpha-synuclein
Ts65Dn mice
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Summary:Alpha-synuclein ( SNCA ), a presynaptic protein, is significantly reduced in individuals with Down syndrome (DS) and Ts65Dn mice, a mouse model of DS. Methylation analyses of promoter proximal CpG sites indicate similar reduction in Ts65Dn mice compared to control mice. Epigallocatechin-3-gallate (EGCG), a polyphenolic catechin present in green tea extract, increases methylation of SNCA promoter proximal CpG sites and expression in Ts65Dn mice. These results suggest a positive link between CpG methylation and SNCA expression in Down syndrome.
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ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-014-8979-z