Influence of 12 Weeks of Jogging on Magnetic Resonance-Determined Left Ventricular Characteristics in Previously Sedentary Subjects Free of Cardiovascular Disease

• Published in: The American journal of cardiology Vol. 103; no. 4; pp. 567 - 571
• Main Authors: Sipola, Petri, MD, PhD, Heikkinen, Jari, PhD, Laaksonen, David E., MD, PhD, MPH, Kettunen, Raimo, MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.02.2009; Elsevier; Elsevier Limited
• Subjects: Adult; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Female; Health behavior; Heart Rate; Heart Ventricles - growth & development; Humans; Hypertrophy, Left Ventricular - diagnosis; Jogging - physiology; Magnetic Resonance Imaging; Male; Medical sciences; Middle age; Middle Aged; NMR; Nuclear magnetic resonance; Physical Endurance; Running; Time Factors; Ventricular Function, Left; Human; Magnetic resonance; Medical imagery; Cardiovascular disease; Circulatory system; Cardiology; Sedentary; Nuclear magnetic resonance imaging; Left ventricle; Jogging; Magnetic properties
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2008.10.020

Hypertrophy of the left ventricle is a diagnostic dilemma in subjects who engage in regular endurance exercise. We studied prospectively whether endurance training in previously sedentary young and middle-aged men and women can alter left ventricular (LV) characteristics. We recruited 33 healthy young and middle-aged subjects (18 women, 15 men, ages 21 to 59 years) to undergo 12 weeks of home-based brisk walking and jogging at a target heart rate ≥120 beats/min for ≥30 minutes 3 times a week. LV characteristics were measured by cine magnetic resonance imaging. Training intensity as estimated by heart rate correlated positively with the increase in LV myocardial area (r = 0.51, p = 0.005) in the 28 men and women completing the study. In the 13 men and women who trained with heart rate of ≥120 beats/min, LV myocardial area was larger after than before training (17.7 ± 2.9 vs 16.8 ± 2.8 cm2 , p <0.05). Moreover, in these subjects LV myocardial area increased more (5.5 ± 9.0% vs −3.0 ± 5.0%) than in the 15 men and women who trained at a lower intensity (p <0.05). LV end-systolic and end-diastolic area and ejection fraction did not change significantly. In conclusion, moderate-to-vigorous endurance training at moderate volumes does not influence LV end-diastolic volume or ejection fraction, but has a minor influence on LV hypertrophy in previously sedentary young and middle-aged men and women.