Renal transplantation in human immunodeficiency virus (HIV)-positive children

Renal transplantation is being performed in adult human immunodeficiency virus (HIV)-positive patients and increasingly in paediatric patients as well. A multidisciplinary team involving an infectious disease professional is required to assist with HIV viral-load monitoring and in choosing the most...

Full description

Saved in:
Bibliographic Details
Published inPediatric nephrology (Berlin, West) Vol. 30; no. 4; pp. 541 - 548
Main Authors McCulloch, Mignon I., Kala, Udai K.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2015
Springer
Springer Nature B.V
Subjects
Adults
Antiretroviral Therapy, Highly Active
Child
Health aspects
HIV
HIV seropositivity
HIV Seropositivity - complications
HIV Seropositivity - diagnosis
HIV-1 - immunology
Human immunodeficiency virus
Humans
Immune system
Immunosuppression - methods
Infections
Kidney diseases
Kidney Failure, Chronic - surgery
Kidney Transplantation
Kidney transplants
Kidneys
Medicine
Medicine & Public Health
Multidisciplinary teams
Nephrology
Pediatrics
Review
Transplantation
Urogenital system
Urology
Viral Load
South Africa
United States > US
Africa
Immunosuppression
Paediatric HIV-infected renal transplantation
Acute kidney injury
HAART
Online AccessGet full text

Cover

More Information
Summary:Renal transplantation is being performed in adult human immunodeficiency virus (HIV)-positive patients and increasingly in paediatric patients as well. A multidisciplinary team involving an infectious disease professional is required to assist with HIV viral-load monitoring and in choosing the most appropriate highly active antiretroviral therapy (HAART). Drug interactions complicate immunosuppressant therapy and require careful management. The acute rejection rates appear to be similar in adults to those in noninfective transplant recipients. Induction with basiliximab and calcineurin-based immunosuppression appears to be safe and effective in these recipients. Prophylaxis is advised for a variety of infections and may need life-long administration, especially in children. Organ shortage remains a significant problem, and kidneys from deceased HIV-positive donors have been used successfully in a small study population. Overall, with careful planning and close follow-up, successful renal transplantation for paediatric HIV-infected recipients is possible.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-014-2782-y