Retinal Pigment Epithelium Degeneration Associated With Subretinal Drusenoid Deposits in Age-Related Macular Degeneration

• Published in: American journal of ophthalmology Vol. 175; pp. 87 - 98
• Main Authors: Xu, Xiaoyu, Liu, Xing, Wang, Xiaolin, Clark, Mark E., McGwin, Gerald, Owsley, Cynthia, Curcio, Christine A., Zhang, Yuhua
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2017; Elsevier Limited
• Subjects: Age; Aged; Choroid - diagnostic imaging; Colleges & universities; Cross-Sectional Studies; Eye diseases; Female; Fluorescein Angiography; Fundus Oculi; Humans; Lasers; Macular degeneration; Macular Degeneration - complications; Macular Degeneration - diagnosis; Male; Medical imaging; Ophthalmology; Ophthalmoscopy; Photoreceptors; Retina; Retinal Drusen - diagnosis; Retinal Drusen - etiology; Retinal Pigment Epithelium - pathology; Retrospective Studies; Standard deviation; Tomography, Optical Coherence - methods; California
• ISSN: 0002-9394; 1879-1891; 1879-1891
• DOI: 10.1016/j.ajo.2016.11.021

To test whether increased light transmission (hypertransmission) through subretinal drusenoid deposits (SDD) into the choroid in age-related macular degeneration (AMD) represented retinal pigment epithelium (RPE) degeneration. Cross-sectional study. Nineteen eyes of 12 patients with early- to intermediate-stage AMD and 18 eyes of 12 normal subjects were evaluated with color fundus photography, optical coherence tomography (OCT), and high-resolution adaptive optics scanning laser ophthalmoscopy (AOSLO) at baseline and 24 months later. SDD were classified using an OCT-based 3-stage grading system. Hypertransmission beneath SDD into the choroid was examined in OCT. SDD microstructure was assessed with AOSLO. To characterize the hypertransmission-associated chorioretinal degeneration, choroidal thickness and photoreceptor length were measured in OCT at 1 mm and 2 mm superior, inferior, temporal, and nasal to the foveal center. OCT disclosed hypertransmission beneath stage 3 SDD in 8 eyes. These lesions showed a distinctive regressing structure in AOSLO, compared with stage 3 lesions without hypertransmission. The phenomenon persisted at follow-up, and new hypertransmission developed as SDD advanced. In eyes with hypertransmission, choroids were thinner than those of normal eyes at all sites (by 44%–56%, P ≤ .0028) and those of eyes with SDD but without hypertransmission at superior and temporal sites (by 31%–46%, P ≤ .039). Photoreceptors were significantly shorter than those in normal eyes (by 6%–26%, P ≤ .0379). Hypertransmission into the choroid, accompanied with SDD regression and thinning of choroid and photoreceptor layers, indicates RPE degeneration associated with advanced stages in the SDD life cycle.