Experimental Verification of the Feasibility of the Cardiovascular Impedance Simulator

• Published in: IEEE transactions on biomedical engineering Vol. 57; no. 5; pp. 1176 - 1183
• Main Authors: Gwak, Kwan-Woong, Paden, Brad E., Antaki, James F., Ahn, Ihn-Seok
• Format: Journal Article
• Language: English
• Published: New York, NY IEEE 01.05.2010; Institute of Electrical and Electronics Engineers; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Biomimetic Materials; Blood Flow Velocity; Calibration; Cardiology; Cardiovascular impedance; Cardiovascular system; Circuits; Circulatory system; Computer Simulation; Computer-Aided Design; Coronary Circulation - physiology; Devices; Dynamic characteristics; Dynamical systems; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care; Equipment Design; Equipment Failure Analysis; Feasibility Studies; feedback control; Fluid dynamics; Fluidics; gear pump; Humans; Impedance; Intensive care medicine; Medical sciences; mock circulatory system; Models, Cardiovascular; Simulation; Testing; Valves; Vascular Resistance - physiology; Ventricular Function - physiology; Human; Intensive cardiocirculatory care; Biomedical equipment; Feedback system; Cardiocirculatory support; feedback control; Experimental study; Feedback; Gear pump; Cardiovascular impedance; Numerical simulation; Medical device; Circulatory system; Simulator; Biomedical engineering; Electrical impedance; mock circulatory system
• ISSN: 0018-9294; 1558-2531
• DOI: 10.1109/TBME.2009.2030498

Mock circulatory systems (MCS) are often used for the development of cardiovascular devices and for the study of the dynamics of blood flow through the cardiovascular system. However, conventional MCS suffer from the repeatability, flexibility, and precision problems because they are typically built up with passive and linear fluidic elements such as compliance chamber, manual valve, and tube. To solve these limitations, we have developed an impedance simulator, comprised of a feedback-controlled positive displacement pump that is capable of generating analogous dynamic characteristics as the conventional fluidic elements would generate, thereby replacing the conventional passive fluidic elements that often cause problems. The impedance simulator is experimentally proven to reproduce the impedance of the various discrete elements, such as resistance and compliance of the cardiovascular system model, as well as the combined impedances of them.