Considerations for diagnostic COVID-19 tests

• Published in: Nature reviews. Microbiology Vol. 19; no. 3; pp. 171 - 183
• Main Authors: Vandenberg, Olivier, Martiny, Delphine, Rochas, Olivier, van Belkum, Alex, Kozlakidis, Zisis
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2021; Nature Publishing Group
• Subjects: 631/326/2521; 631/326/596/4130; 692/308; Biomedical and Life Sciences; Coronaviridae; Coronaviruses; COVID-19; COVID-19 - diagnosis; COVID-19 Testing - economics; COVID-19 Testing - methods; COVID-19 Testing - standards; Developed Countries; Developing Countries; Diagnostic systems; Diagnostic Test Approval; Diagnostic tests; Humans; Immunoassays; Infection control; Infectious Diseases; Life Sciences; Manufacturing Industry; Medical diagnosis; Medical Microbiology; Methods; Microbiology; Outbreaks; Pandemics; Parasitology; Point-of-Care Testing; Public health administration; Review; Review Article; SARS-CoV-2 - genetics; SARS-CoV-2 - isolation & purification; Time Factors; Viral diseases; Virology; World Health Organization; Belgium
• ISSN: 1740-1526; 1740-1534; 1740-1534
• DOI: 10.1038/s41579-020-00461-z

During the early phase of the coronavirus disease 2019 (COVID-19) pandemic, design, development, validation, verification and implementation of diagnostic tests were actively addressed by a large number of diagnostic test manufacturers. Hundreds of molecular tests and immunoassays were rapidly developed, albeit many still await clinical validation and formal approval. In this Review, we summarize the crucial role of diagnostic tests during the first global wave of COVID-19. We explore the technical and implementation problems encountered during this early phase in the pandemic, and try to define future directions for the progressive and better use of (syndromic) diagnostics during a possible resurgence of COVID-19 in future global waves or regional outbreaks. Continuous global improvement in diagnostic test preparedness is essential for more rapid detection of patients, possibly at the point of care, and for optimized prevention and treatment, in both industrialized countries and low-resource settings. In this Review, Vandenberg et al. explore the crucial role of diagnostic tests during the first global wave of coronavirus disease 2019 (COVID-19) and the technical and implementation problems encountered during the early phase of the pandemic, and they define future directions for the progressive and better use of diagnostics during a possible resurgence of COVID-19 in future global waves or regional outbreaks.