Pendelluft in patients with acute respiratory distress syndrome during trigger and reverse triggering breaths

• Published in: Scientific reports Vol. 13; no. 1; pp. 22143 - 12
• Main Authors: Lin, Wei-Chieh, Su, Pei-Fang, Chen, Chang-Wen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.12.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/443/1784; 692/699/1785/3193; Anesthesia; Blood pressure; Diaphragm (Anatomy); Electrical impedance; Esophagus; Hemodynamics; Humanities and Social Sciences; Mechanical ventilation; Mechanics; multidisciplinary; Patients; Pressure transducers; Regions; Respiration; Respiratory distress syndrome; Respiratory system; Science; Science (multidisciplinary); Tomography; Ventilation; Ventilators
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-49038-9

Pendelluft, the shift of air from non-dependent to dependent lung regions, is known to occur during active breathing in ventilated patients. However, information about pendelluft in ARDS patients under assisted mechanical ventilation is limited. In this prospectively collected and retrospectively analyzed study, we combined electrical impedance tomography and respiratory mechanics monitoring to quantitatively examine pendelluft in trigger and reverse triggering breaths in 20 mechanically ventilated patients with ARDS during the transition from controlled to active breaths under volume-cycled ventilation. Besides the 10 resting breaths in each patient, 20% of the counted active breaths were selected based on three levels of esophageal pressure swing (∆P es ): low (< 5 cm H 2 O, breaths = 471), moderate (≥ 5, < 10 cm H 2 O, breaths = 906), and high effort (≥ 10 cm H 2 O, breaths = 565). The pendelluft response to breathing efforts was significantly greater in trigger breaths than in reverse triggering breaths ( p  < 0.0001). Based on the pendelluft-∆P es slope (ml/cmH 2 O), there were two distinct patterns of effort-related pendelluft (high vs. low pendelluft group). For trigger breaths, the high pendelluft group (n = 9, slope 0.7–2.4 ml/cmH 2 O) was significantly associated with lower peak airway/plateau pressure and lower respiratory system/lung elastance than the low pendelluft group (n = 11, slope − 0.1 to 0.3 ml/cmH 2 O). However, there was no difference in respiratory mechanics between high and low pendelluft groups for reverse triggering breathes. The use of ∆P es to predict pendelluft was found to have a low positive predictive value.