Overlapping Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis household transmission and mobile genetic element exchange

• Published in: Nature communications Vol. 15; no. 1; p. 3477
• Main Authors: Xie, Ouli, Zachreson, Cameron, Tonkin-Hill, Gerry, Price, David J., Lacey, Jake A., Morris, Jacqueline M., McDonald, Malcolm I., Bowen, Asha C., Giffard, Philip M., Currie, Bart J., Carapetis, Jonathan R., Holt, Deborah C., Bentley, Stephen D., Davies, Mark R., Tong, Steven Y. C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 45; 45/23; 631/114/2785; 692/308/174; 692/699/255/1318; Adolescent; Adult; Antimicrobial agents; Antimicrobial resistance; Australia; Bacteria; Cardiovascular disease; Child; Child, Preschool; Drug resistance; Drug Resistance, Bacterial - genetics; Epidemiology; Family Characteristics; Female; Gene transfer; Gene Transfer, Horizontal; Genes; Genome, Bacterial - genetics; Genomes; Genomic analysis; Homology; Horizontal transfer; Households; Humanities and Social Sciences; Humans; Impetigo; Infections; Interspersed Repetitive Sequences - genetics; Longitudinal Studies; Male; multidisciplinary; Native peoples; Pathogens; Phenotypes; Science; Science (multidisciplinary); Species; Streptococcal Infections - microbiology; Streptococcal Infections - transmission; Streptococcus - genetics; Streptococcus - isolation & purification; Streptococcus dysgalactiae; Streptococcus infections; Streptococcus pyogenes; Streptococcus pyogenes - classification; Streptococcus pyogenes - genetics; Streptococcus pyogenes - isolation & purification; Surveillance; Vaccines; Virulence; Young Adult; Australia

Streptococcus dysgalactiae subspecies equisimilis (SDSE) and Streptococcus pyogenes share skin and throat niches with extensive genomic homology and horizontal gene transfer (HGT) possibly underlying shared disease phenotypes. It is unknown if cross-species transmission interaction occurs. Here, we...