Fate mapping analysis reveals a novel murine dermal migratory Langerhans-like cell population

• Published in: eLife Vol. 10
• Main Authors: Sheng, Jianpeng, Chen, Qi, Wu, Xiaoting, Dong, Yu Wen, Mayer, Johannes, Zhang, Junlei, Wang, Lin, Bai, Xueli, Liang, Tingbo, Sung, Yang Ho, Goh, Wilson Wen Bin, Ronchese, Franca, Ruedl, Christiane
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications Ltd 26.03.2021; eLife Sciences Publications, Ltd
• Subjects: Antigen presentation; Antigen-presenting cells; Bone marrow; CD8 antigen; Cell fate; Cell migration; Contact dermatitis; dendritic cell; Dendritic cells; Dermis; Effector cells; Epidermis; Fate maps; Flow cytometry; Gene mapping; Genetic analysis; Haptens; Hypersensitivity; Immunological tolerance; Immunology and Inflammation; Langerhans cell; Langerhans cells; lymph node; Lymph nodes; Lymphatic system; Lymphocytes T; Osteoprogenitor cells; Population; skin; Skin diseases; mouse; Langerhans cell; inflammation; lymph node; cell migration; skin; immunology; dendritic cell; dermis

Dendritic cells residing in the skin represent a large family of antigen-presenting cells, ranging from long-lived Langerhans cells (LC) in the epidermis to various distinct classical dendritic cell subsets in the dermis. Through genetic fate mapping analysis and single-cell RNA-sequencing, we have...