Advances in coatings on magnesium alloys for cardiovascular stents – A review

• Published in: Bioactive materials Vol. 6; no. 12; pp. 4729 - 4757
• Main Authors: Zhang, Zhao-Qi, Yang, Yong-Xin, Li, Jing-An, Zeng, Rong-Chang, Guan, Shao-Kang
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.12.2021; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Cardiovascular stent; Functional properties; Magnesium alloy; Rapid endothelialization; Surface modification; Surface modification; Functional properties; Rapid endothelialization; Cardiovascular stent; Magnesium alloy
• ISSN: 2452-199X; 2452-199X
• DOI: 10.1016/j.bioactmat.2021.04.044

Magnesium (Mg) and its alloys, as potential biodegradable materials, have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and biocompatibility. Nevertheless, the occurrence of thrombosis, inflammation, and restenosis of implanted Mg alloy stents caused by their poor corrosion resistance and insufficient endothelialization restrains their anticipated clinical applications. Numerous surface treatment tactics have mainly striven to modify the Mg alloy for inhibiting its degradation rate and enduing it with biological functionality. This review focuses on highlighting and summarizing the latest research progress in functionalized coatings on Mg alloys for cardiovascular stents over the last decade, regarding preparation strategies for metal oxide, metal hydroxide, inorganic nonmetallic, polymer, and their composite coatings; and the performance of these strategies in regulating degradation behavior and biofunction. Potential research direction is also concisely discussed to help guide biological functionalized strategies and inspire further innovations. It is hoped that this review can give assistance to the surface modification of cardiovascular Mg-based stents and promote future advancements in this emerging research field. [Display omitted] •This article overviews the development course and present situation of Mg-based stents.•The crucial issues of limiting the clinical application of Mg-based stents are proposed in this article.•This article summarizes the recent research progress in the surface modification tactic of Mg-based stents.•The future directions of modification strategies of Mg-based stents are discussed in this article.