Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils
The adaptor Fc receptor common γ-chain transduces signals for many immunoreceptors. Taki and colleagues find that this adaptor 'reroutes' interleukin 3 signals to induce interleukin 4 production and T helper 2 differentiation. The Fc receptor common γ-chain (FcRγ) is a widely expressed ada...
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Published in | Nature immunology Vol. 10; no. 2; pp. 214 - 222 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Nature Publishing Group US
01.02.2009
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | The adaptor Fc receptor common γ-chain transduces signals for many immunoreceptors. Taki and colleagues find that this adaptor 'reroutes' interleukin 3 signals to induce interleukin 4 production and T helper 2 differentiation.
The Fc receptor common γ-chain (FcRγ) is a widely expressed adaptor bearing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. We show here that basophils lacking FcRγ developed normally and proliferated efficiently in response to interleukin 3 (IL-3) but were very impaired in IL-3-induced production of IL-4 and in supporting T helper type 2 differentiation. Through its transmembrane portion, FcRγ associated constitutively with the common β-chain of the IL-3 receptor and signaled by recruiting the kinase Syk. Retrovirus-mediated complementation demonstrated the essential function of the ITAM of FcRγ in IL-3 signal transduction. Our results identify a previously unknown mechanism whereby FcRγ functions to 'route' selective cytokine-triggered signals into the ITAM-mediated IL-4 production pathway. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1529-2908 1529-2916 |
DOI: | 10.1038/ni.1686 |