Lipoprotein(a) is associated with DNA damage in patients with heterozygous familial hypercholesterolemia

Heterozygous familial hypercholesterolemia (HeFH) is a common autosomal-dominant inherited disorder associated with atherosclerotic cardiovascular disease (ASCVD). HeFH subjects have a higher lipoprotein(a), i.e. Lp(a), concentration than the general population. Patients with FH are exposed to eleva...

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Published inScientific reports Vol. 14; no. 1; pp. 2564 - 11
Main Authors Woźniak, Ewelina, Broncel, Marlena, Woźniak, Agnieszka, Satała, Joanna, Pawlos, Agnieszka, Bukowska, Bożena, Gorzelak-Pabiś, Paulina
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 31.01.2024
Nature Publishing Group
Nature Portfolio
Subjects
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631/45/287
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692/699/75
Arteriosclerosis
Cardiovascular diseases
Deoxyribonucleic acid
DNA
DNA damage
Hereditary diseases
Humanities and Social Sciences
Hypercholesterolemia
Low density lipoprotein
multidisciplinary
Oxidative stress
Science
Science (multidisciplinary)
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Summary:Heterozygous familial hypercholesterolemia (HeFH) is a common autosomal-dominant inherited disorder associated with atherosclerotic cardiovascular disease (ASCVD). HeFH subjects have a higher lipoprotein(a), i.e. Lp(a), concentration than the general population. Patients with FH are exposed to elevated levels of LDL from birth and ox-LDL may induce other oxidation pathways. The aim of the study was to determine the levels of markers of oxidative stress and DNA damage in patients with HeFH and describe the effect of Lp(a) on the resulting damage. Higher DNA damage was identified in patients with HeFH compared to the normolipidemic ones, and ASCVD was associated with greater damage. Oxidative stress markers were elevated in HeFH patients; however, only ox-LDL was higher in the ASCVD group and its level correlated with DNA damage. A positive correlation was found between DNA damage and Lp(a) concentration in the HeFH patients. Higher levels of Lp(a) were associated with greater DNA damage, especially in patients with HeFH and ASCVD. In HeFH patients, the optimal Lp(a) cut-off point associated with ASCVD is > 23.45 nmol/L, i.e. much lower than for the general population; however this cut-off point needs validation in a larger group of HeFH patients.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-52571-w