Treatment outcomes of stereotactic body radiation therapy for primary and metastatic sarcoma of the spine
Abstract Purpose This study evaluated the treatment outcomes of spine stereotactic body radiation therapy (SBRT) in sarcoma patients. Materials and methods A total of 44 sarcoma patients and 75 spinal lesions (6 primary tumors, 69 metastatic tumors) treated with SBRT were retrospectively reviewed be...
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Published in | Radiation oncology (London, England) Vol. 18; no. 1; pp. 1 - 156 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
London
BioMed Central Ltd
22.09.2023
BioMed Central BMC |
Subjects | |
Online Access | Get full text |
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Summary: | Abstract
Purpose
This study evaluated the treatment outcomes of spine stereotactic body radiation therapy (SBRT) in sarcoma patients.
Materials and methods
A total of 44 sarcoma patients and 75 spinal lesions (6 primary tumors, 69 metastatic tumors) treated with SBRT were retrospectively reviewed between 2006 and 2017. The median radiation dose was 33 Gy (range, 18–45 Gy) in 3 fractions (range, 1–5) prescribed to the 75% isodose line.
Results
The median follow-up duration was 18.2 months. The 1-year local control was 76.4%, and patients treated with single vertebral body were identified as a favorable prognostic factor on multivariate analyses. Progression-free survival at 1 year was 31.9%, with the interval between initial diagnosis and SBRT and extent of disease at the time of treatment being significant prognostic factors. The 1-year overall survival was 80.5%, and PTV and visceral metastases were independently associated with inferior overall survival.
Conclusion
SBRT for spinal sarcoma is effective in achieving local control, particularly when treating a single vertebral level with a limited extent of disease involvement, resulting in an excellent control rate. The extent of disease at the time of SBRT is significantly correlated with survival outcomes and should be considered when treating spine sarcoma. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1748-717X 1748-717X |
DOI: | 10.1186/s13014-023-02346-w |