Synergistic interaction of benign prostatic hyperplasia and prostatitis on prostate cancer risk

• Published in: British journal of cancer Vol. 108; no. 9; pp. 1778 - 1783
• Main Authors: HUNG, S.-C, LAI, S.-W, TSAI, P.-Y, CHEN, P.-C, WU, H.-C, LIN, W.-H, SUNG, F.-C
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 14.05.2013
• Subjects: Age; Aged; Aged, 80 and over; Asia; Biological and medical sciences; Clinical Study; Comorbidity; Datasets; Diabetes; Early Detection of Cancer; Hospitals; Humans; Hyperplasia; Male; Medical research; Medical sciences; Medical screening; Metabolic syndrome; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Multivariate Analysis; National health insurance; Nephrology. Urinary tract diseases; Patients; Population; Prostate cancer; Prostate-Specific Antigen; Prostatic Hyperplasia - epidemiology; Prostatic Neoplasms - epidemiology; Prostatitis - epidemiology; Risk; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Urology; Asia; United States > US; China; Taiwan; Endocrinopathy; Urinary system disease; Prostate disease; Diabetes mellitus; Risk; Malignant tumor; Cancerology; Risk factor; interaction; Benign prostatic hyperplasia; Drug interaction; Prostatitis; Benign neoplasm; Male genital diseases; Prostate cancer; diabetes; Cancer
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/bjc.2013.184

The incidence of prostate cancer is much lower in Asian men than in Western men. This study investigated whether prostate cancer is associated with prostatitis, benign prostatic hyperplasia (BPH), and other medical conditions in the low-incidence population. From the claims data obtained from the universal National Health Insurance of Taiwan, we identified 1184 patients with prostate cancer diagnosed from 1997 to 2008. Controls comprised 4736 men randomly selected from a cancer-free population. Both groups were 50 years of age or above. Medical histories between the two groups were compared. Multivariate logistic regression analysis showed that prostatitis and BPH had stronger association with prostate cancer than the other medical conditions tested. Compared with men without prostatitis and BPH, a higher odds ratio (OR) for prostate cancer was associated with BPH (26.2, 95% confidence interval (CI) 20.8-33.0) than with prostatitis (10.5, 95% CI=3.36-32.7). Men with both conditions had an OR of 49.2 (95% CI=34.7-69.9). Men with prostate cancer have strong association with prostatitis and/or BPH. Prostatitis interacts with BPH, resulting in higher estimated relative risk of prostate cancer in men suffering from both conditions.