Protection effect of Xuanfudaizhetang on reflux esophagitis in rats

• Published in: Asian Pacific journal of tropical medicine Vol. 7; no. 4; pp. 267 - 270
• Main Authors: Liang, Bing, Liu, Zhong-Hua, Wei, Hai-Tao, Zhang, Zhi, Shi, Gong-Ning
• Format: Journal Article
• Language: English
• Published: India Elsevier B.V 01.04.2014; Department of Cardiothoracic Surgery, Huahe Hospital, Henan University, Kaifeng 475000, Henan, China%Medical College, Henan University, Kaifeng 475000, Henan, China
• Subjects: Animals; Drugs, Chinese Herbal - pharmacology; Esophageal; Esophageal mucosa; esophagitis; Esophagitis, Peptic - drug therapy; Esophagus - drug effects; Esophagus - pathology; Gastric Mucosa - drug effects; Gastric Mucosa - pathology; Gastrointestinal Agents - pharmacology; Helicobacter; Male; mucosa; PH value; Protective Agents - pharmacology; Rats; Rats, Wistar; Reflux; Reflux esophagitis; Treatment; value; Weight Gain - drug effects; Xuanfudaizhetang; Treatment; Xuanfudaizhetang; Reflux esophagitis; Esophageal mucosa; PH value
• ISSN: 1995-7645; 2352-4146
• DOI: 10.1016/S1995-7645(14)60035-3

Objective:To study protection effect of Xuanfudaizhetang on reflux esophagitis in rats.Methods:A total of 50 Wistar rats were randomly divided into groups A,B,C,D and E with 10 in each.Reflux esophagitis model in rats was established by incomplete helicobacter seam+lower esophagus sphincterotomy.All rats were divided into 5 groups:group A as control group,group B as model group,group C with saline lavage treatment,group D with motilium treatment,group E with Xuanfudaizhetang lavage treatment.Recovery of esophageal,gastric mucosa and pH changes of rats were compared between groups.Results:Weight gain in group D and E was significantly higher in than group C;the esophageal mucosa grades and esophagus tissue pathological morphology grades of group D and E were higher than that of group B and C with significant difference between groups(P<0.05);pH of lower esophageal mucosa in group D and E increased significantly than that in the group B and C(P<0.05),and the distal mucosal pH dropped significantly in the group B and C(P<0.05).Conclusions:Xuanfudaizhetang can obviously improve the pH of lower esophageal mucosa in rats with reflux esophagitis,decrease pH value of gastric mucosal,thus improve esophageal mucosa pathological conditions to achieve therapeutic effect on reflux esophagitis.