Bioengineering of bacteria for cancer immunotherapy

Here, we provide a brief overview of the approaches and strategies underlying bacteria-based cancer immunotherapy (BCiT). We also describe and summarize research in the field of synthetic biology, which aims to regulate bacterial growth and gene expression for immunotherapeutic use. Finally, we disc...

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Bibliographic Details
Published inNature communications Vol. 14; no. 1; p. 3553
Main Authors Nguyen, Dinh-Huy, Chong, Ari, Hong, Yeongjin, Min, Jung-Joon
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 15.06.2023
Nature Publishing Group
Nature Portfolio
Subjects
631/67
631/67/2195
631/67/327
Bacteria
Bioengineering
Cancer
Cancer immunotherapy
Chemokines
Circuits
Comment
Cytokines
Cytotoxicity
E coli
Gene expression
Genetic engineering
Humanities and Social Sciences
Immunotherapy
Ligands
multidisciplinary
Payloads
Salmonella
Science
Science (multidisciplinary)
Synthetic biology
Tumor necrosis factor-TNF
Tumors
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Summary:Here, we provide a brief overview of the approaches and strategies underlying bacteria-based cancer immunotherapy (BCiT). We also describe and summarize research in the field of synthetic biology, which aims to regulate bacterial growth and gene expression for immunotherapeutic use. Finally, we discuss the current clinical status and limitations of BCiT.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-39224-8