Peripheral blood BDNF and soluble CAM proteins as possible markers of prolonged disorders of consciousness: a pilot study

Although clinical examination still represents the gold standard for the differential diagnosis of prolonged disorders of consciousness (pDoC), the introduction of innovative markers is essential for diagnosis and prognosis, due to the problem of covert cognition. We evaluated the brain-derived neur...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 14; no. 1; p. 341
Main Authors Coppola, L., Smaldone, G., Grimaldi, A. M., Estraneo, A., Magliacano, A., Soddu, A., Ciccarelli, G., Salvatore, M., Cavaliere, C.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 03.01.2024
Nature Publishing Group
Nature Portfolio
Subjects
631/378
692/617
692/617/375
Blood Proteins
Brain-Derived Neurotrophic Factor
CD44 antigen
Cell adhesion molecules
Cognition
Consciousness
Consciousness Disorders - diagnosis
Differential diagnosis
E-selectin
EEG
Humanities and Social Sciences
Humans
multidisciplinary
Neural cell adhesion molecule
Neuroimaging
Peripheral blood
Pilot Projects
Proteins
Science
Science (multidisciplinary)
Substantia alba
Unconsciousness
Vascular Cell Adhesion Molecule-1
Online AccessGet full text

Cover

More Information
Summary:Although clinical examination still represents the gold standard for the differential diagnosis of prolonged disorders of consciousness (pDoC), the introduction of innovative markers is essential for diagnosis and prognosis, due to the problem of covert cognition. We evaluated the brain-derived neurotrophic factor protein (BDNF) and the soluble cell adhesion molecules proteins (CAMs) in a cohort of prolonged disorders of consciousness patients to identify a possible application in the clinical context. Furthermore, peripheral blood determinations were correlated with imaging parameters such as white matter hyperintensities (WMH), cranial standardized uptake value (cSUV), electroencephalography (EEG) data and clinical setting. Our results, although preliminary, identify BDNF as a possible blood marker for the diagnosis of pDoC (p value 0.001), the soluble CAMs proteins CD44, Vcam-1, E-selectin (p value < 0.01) and Icam-3 (p value < 0.05) showed a higher peripheral blood value in pDoC compared with control. Finally, soluble Ncam protein could find useful applications in the clinical evolution of the pDoC, showing high levels in the MCS and EMCS subgroups (p value < 0. 001) compared to VS/UWS.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-50581-8