Neutrophil-to-lymphocyte ratio as a promising non-invasive biomarker for symptom assessment and diagnosis of interstitial cystitis/bladder pain syndrome

• Published in: BMC urology Vol. 23; no. 1; pp. 1 - 180
• Main Authors: Ke, Hanwei, Zhu, Lin, Wang, Qi, Xu, Kexin
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 08.11.2023; BioMed Central; BMC
• Subjects: Analysis; Biomarker; Biomarkers; Biopsy; Bladder; Blood; Body mass index; Cystitis; Diabetes; Diagnosis; Health aspects; Interstitial cystitis; Leukocytes (neutrophilic); Lymphocytes; Medical examination; Medical records; Medical research; Medicine, Experimental; Neutrophil-to-lymphocyte ratio; Neutrophils; Nocturia; Normal distribution; Pain; Patients; Ulcers; Urinary incontinence; Urinary tract diseases; Urinary tract infections; Urination; Urine; Urodynamic Disease; Urogenital system; Urology; Taiwan
• ISSN: 1471-2490; 1471-2490
• DOI: 10.1186/s12894-023-01353-z

Abstract Background Our study aims to investigate the association between the serum neutrophil-to-lymphocyte ratio (NLR) and interstitial cystitis (IC), as well as to explore whether NLR can serve as a diagnostic marker to distinguish IC from overactive bladder (OAB). We postulate that elevated NLR levels are intricately linked to the onset and clinical presentation of IC, and that the NLR profiles in OAB patients exhibit discernible disparities from those of IC patients. Methods In a retrospective analysis, we scrutinized the medical records of 70 women diagnosed with IC/BPS, 20 women diagnosed with OAB, and a randomly selected cohort of 150 healthy women who underwent physical examinations during the same temporal frame. A comprehensive panel of blood tests was administered to all participants, and NLR was determined through the calculation of the neutrophil-to-lymphocyte proportion. Additionally, symptom assessment questionnaires and urination diaries were collected from IC/BPS patients. Results NLR levels exhibited significant distinctions among the IC/BPS, Normal, and OAB groups (P < 0.001). Within the IC/BPS group, Hunner type interstitial cystitis (HIC) demonstrated notably divergent NLR levels in comparison to non-Hunner type interstitial cystitis (NHIC) (p = 0.001). Additionally, we observed positive correlations between NLR and Nighttime voids (r = 0.268, p = 0.029), ICPI (r = 0.327, p = 0.007), ICSI (r = 0.369, p = 0.002), PUF Symptom Scale (r = 0.263, p = 0.032), and PUF (r = 0.297, p = 0.015). The receiver operating characteristic (ROC) analysis yielded an area under the curve (AUC) of 0.765 for NLR in distinguishing IC/BPS from the Normal group, and an AUC of 0.707 in discerning IC from OAB. Furthermore, the AUC of NLR was 0.723 for identifying HIC and NHIC patients. Conclusions Our study unveils the prospective utility of serum NLR as a promising biomarker for both diagnostic and symptom evaluation purposes in IC/BPS patients. It effectively demarcates this condition from OAB, which presents with similar clinical features. Consequently, NLR demonstrates potential as a non-invasive diagnostic instrument to distinguish between the subtypes of IC, particularly HIC and NHIC, which manifest similar symptoms within the IC/BPS spectrum.