Successful Hand Transplantation — One-Year Follow-up

In 1996, the Louisville Hand Transplant Team was formed to examine the possibility of performing a human hand transplantation. One of our first goals was to develop procedures for the transplantation of allografts of extremities in large animals. 1 , 2 In contrast to prior studies of hand transplant...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 343; no. 7; pp. 468 - 473
Main Authors Jones, Jon W, Gruber, Scott A, Barker, John H, Breidenbach, Warren C
Format Journal Article
LanguageEnglish
Published Boston, MA Massachusetts Medical Society 17.08.2000
Subjects
basiliximab
Biological and medical sciences
Medical sciences
mycophenolate mofetil
Orthopedic surgery
prednisone
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
tacrolimus
Human
Immunopathology
Indication
Surgery
Treatment efficiency
Diseases of the osteoarticular system
Risk factor
Graft versus host reaction
Transplantation
Immunosuppressive agent
Therapeutic protocol
Hand
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Summary:In 1996, the Louisville Hand Transplant Team was formed to examine the possibility of performing a human hand transplantation. One of our first goals was to develop procedures for the transplantation of allografts of extremities in large animals. 1 , 2 In contrast to prior studies of hand transplantation in primates, in which very high doses of cyclosporine and prednisone did not prevent rejection episodes and had many adverse effects, 3 – 5 we found that in pigs that received extremity transplants, rejection could be delayed with a regimen of cyclosporine, mycophenolate mofetil, and prednisone or a regimen of tacrolimus, mycophenolate mofetil, and prednisone. . . .
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM200008173430704