A surface-eroding poly(1,3-trimethylene carbonate) coating for magnesium based cardiovascular stents with stable drug release and improved corrosion resistance

• Published in: Bioactive materials Vol. 7; pp. 144 - 153
• Main Authors: Tang, Hongyan, Li, Shuangshuang, Zhao, Yuan, Liu, Cunli, Gu, Xuenan, Fan, Yubo
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.01.2022; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Cardiovascular stents; Drug release; Magnesium alloy; Polymeric coating; Surface erosion; Drug release; Surface erosion; Cardiovascular stents; Polymeric coating; Magnesium alloy
• ISSN: 2452-199X; 2452-199X
• DOI: 10.1016/j.bioactmat.2021.05.045

Magnesium alloys with integration of degradability and good mechanical performance are desired for vascular stent application. Drug-eluting coatings may optimize the corrosion profiles of magnesium substrate and reduce the incidence of restenosis simultaneously. In this paper, poly (trimethylene carbonate) (PTMC) with different molecular weight (50,000 g/mol named as PTMC5 and 350,000 g/mol named as PTMC35) was applied as drug-eluting coatings on magnesium alloys. A conventional antiproliferative drug, paclitaxel (PTX), was incorporated in the PTMC coating. The adhesive strength, corrosion behavior, drug release and biocompatibility were investigated. Compared with the PLGA control group, PTMC coating was uniform and gradually degraded from surface to inside, which could provide long-term protection for the magnesium substrate. PTMC35 coated samples exhibited much slower corrosion rate 0.05 μA/cm2 in comparison with 0.11 μA/cm2 and 0.13 μA/cm2 for PLGA and PTMC5 coated counterparts. In addition, PTMC35 coating showed more stable and sustained drug release ability and effectively inhibited the proliferation of human umbilical vein vascular smooth muscle cells. Hemocompatibility test indicated that few platelets were adhered on PTMC5 and PTMC35 coatings. PTMC35 coating, exhibiting surface erosion behavior, stable drug release and good biocompatibility, could be a good candidate as a drug-eluting coating for magnesium-based stent. [Display omitted] •PTMC coatings degrade from exterior to interior and provide sustained protection of the magnesium substrate from in vitro corrosion.•The high molecular weight PTMC coated magnesium substrate exhibits the slowest in vitro corrosion.•The high molecular weight PTMC coating shows continuous and stable drug releasing behavior which can effectively inhibit the HUVSMC proliferation.