Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021

In Egypt, the endemicity of avian influenza viruses is a serious concern. Since 2016, several outbreaks of H5N8 have been recorded among domestic poultry in various areas of the country. Active surveillance of domestic poultry across several governorates in Egypt from 2017 to 2021 detected at least...

Full description

Saved in:
Bibliographic Details
Published inMicroorganisms (Basel) Vol. 10; no. 3; p. 595
Main Authors Kandeil, Ahmed, Moatasim, Yassmin, El Taweel, Ahmed, El Sayes, Mohamed, Rubrum, Adam, Jeevan, Trushar, McKenzie, Pamela P., Webby, Richard J., Ali, Mohamed A., Kayali, Ghazi, El-Shesheny, Rabeh
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 09.03.2022
MDPI
Subjects
Amino acids
Antigenic characteristics
Antigenic drift
antigenic variation
Antigens
antiviral agents
Avian flu
avian influenza
Bird migration
Drug resistance
Egypt
genes
Genomes
Genotypes
H5N8
Hemagglutinins
Heterogeneity
highly pathogenic avian influenza
indigenous species
Influenza
Influenza A
monitoring
Mutation
Pathogenicity
Pathogens
phylogenetic analysis
Phylogenetics
Poultry
Poultry production
Public health
reassortment
Viral infections
Virulence
Viruses
England
United Kingdom > UK
United States > US
China
Germany
Egypt
highly pathogenic avian influenza
reassortment
phylogenetic analysis
H5N8
Egypt
Online AccessGet full text

Cover

More Information
Summary:In Egypt, the endemicity of avian influenza viruses is a serious concern. Since 2016, several outbreaks of H5N8 have been recorded among domestic poultry in various areas of the country. Active surveillance of domestic poultry across several governorates in Egypt from 2017 to 2021 detected at least six genotypes of Highly Pathogenic Avian Influenza (HPAI) H5N8 viruses with evidence of partial or complete annual replacement of dominant strains. Although all Egyptian H5N8 viruses had clade 2.3.4.4b hemagglutinin (HA) genes, the remaining viral gene segments were from multiple geographic origins, indicating that the H5N8 isolates resulted from multiple introductions. Mutations in the viral proteins associated with pathogenicity and antiviral drug resistance were detected. Some mutations in the HA resulted in antigenic drift. Heterogeneity in circulating H5N8 HPAI threatens poultry production and public health.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
These authors contributed equally to this work.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms10030595